Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Continuous Renal Replacement Therapy01:30

Continuous Renal Replacement Therapy

1.1K
Continuous Renal Replacement Therapy, also known as CRRT, is a procedural treatment for acute kidney injury (AKI) that gradually removes uremic toxins and fluids while maintaining acid-base balance and stabilizing electrolytes. It is particularly useful for hemodynamically unstable patients. Unlike intermittent hemodialysis, which is faster, CRRT provides a gentler approach over 24 hours, closely mimicking the function of natural kidneys. However, CRRT is not ideal for patients with...
1.1K
Cardiac Catheterization III: Left Heart Catheterization01:24

Cardiac Catheterization III: Left Heart Catheterization

751
Left heart catheterization is an invasive diagnostic procedure used to evaluate the function and structure of the left side of the heart. It is generally performed to diagnose and treat cardiovascular conditions such as valve abnormalities, coronary artery disease, and congenital heart defects.Diagnostic and therapeutic purposesLeft heart catheterization serves various diagnostic and therapeutic purposes, including:Assessing coronary artery bypass grafts.Evaluating coronary artery disease in...
751
Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy01:26

Extracorporeal Removal of Drugs: Continuous Renal Replacement Therapy

229
Continuous Renal Replacement Therapy (CRRT) is an essential intervention for patients experiencing severe kidney dysfunction. This therapy offers a continuous mechanism for removing fluids and toxins from the bloodstream, leveraging the patient’s blood pressure to facilitate filtration through a specialized filter. This method contrasts with intermittent dialysis, providing a gentler and more consistent removal of waste products and excess fluid, which is particularly beneficial in...
229
Predicting Reaction Outcomes02:24

Predicting Reaction Outcomes

10.9K
Kinetics describes the rate and path by which a reaction occurs. In contrast, thermodynamics deals with state functions and describes the properties, behavior, and components of a system. It is not concerned with the path taken by the process and cannot address the rate at which a reaction occurs. Although it does provide information about what can happen during a reaction process, it does not describe the detailed steps of what appears on an atomic or a molecular level. On the other hand,...
10.9K
Outcomes of Glycolysis01:13

Outcomes of Glycolysis

107.4K
Nearly all the energy used by cells comes from the bonds that make up complex organic compounds. These organic compounds are broken down into simpler molecules, such as glucose. As a result, cells extract energy from glucose over many chemical reactions—a process called cellular respiration.
Cellular respiration can occur aerobically (with oxygen) or anaerobically (without oxygen). In the presence of oxygen, cellular respiration starts with glycolysis and continues with pyruvate...
107.4K
Guidelines for Writing Outcome01:11

Guidelines for Writing Outcome

4.0K
When developing expected outcomes for a patient care plan, the nurse should adhere to the following recommendations:
Patient outcomes reflect the patient's response to the goal rather than what the nurse aims to achieve. Terminology should be observable and measurable to avoid the reader's interpretation. The desired outcome should be realistic and achievable in the designated care timeframe. Expected outcomes should align with adjunctive therapies. The outcome should enhance care...
4.0K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

ECG Noise Filter of Patients with Implanted Left Ventricular Assist Device.

Heart rhythm·2026
Same author

Virtual Dementia in the Digital Age: Neurocognitive Mechanisms, Behavioural Impact and Public Health Implications of Technology Overuse.

Annals of neurosciences·2026
Same author

Insurance and Treatment Patterns in Pulmonary Arterial Hypertension: The Pulmonary Hypertension Association Registry.

Annals of the American Thoracic Society·2026
Same author

Offsetting costs of new ablation technologies with increased procedural efficiency and volume.

Heart rhythm·2026
Same author

Determining the individualized probability of myocardial recovery: The multicenter RecoverHeart calculator.

The Journal of heart and lung transplantation : the official publication of the International Society for Heart Transplantation·2026
Same author

Lessons Learned from the HVAD Post-Approval Study Registry: Implications for Investigating Future Ventricular Assist Device Technology.

Journal of cardiac failure·2026

Related Experiment Video

Updated: Feb 8, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.0K

Cardiac Resynchronization Therapy and Clinical Outcomes in Continuous Flow Left Ventricular Assist Device Recipients.

Rakesh Gopinathannair1, Henri Roukoz2, Adarsh Bhan3

  • 1University of Louisville, Louisville, KY rakesh.gopinathannair@louisville.edu drrakeshg@yahoo.com.

Journal of the American Heart Association
|June 17, 2018
PubMed
Summary

Cardiac resynchronization therapy (CRT) did not improve survival or reduce hospitalizations in patients with continuous flow left ventricular assist devices (CF-LVADs). This therapy was associated with more pulse generator changes, suggesting it offers no added benefit in this population.

Keywords:
cardiac resynchronization therapyheart failureimplanted cardioverter defibrillatorleft ventricular assist deviceventricular arrhythmia

More Related Videos

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.1K
In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.2K

Related Experiment Videos

Last Updated: Feb 8, 2026

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing
12:45

Benefits of Cardiac Resynchronization Therapy in an Asynchronous Heart Failure Model Induced by Left Bundle Branch Ablation and Rapid Pacing

Published on: December 11, 2017

11.0K
Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock
07:39

Use of a Percutaneous Ventricular Assist Device/Left Atrium to Femoral Artery Bypass System for Cardiogenic Shock

Published on: August 16, 2021

4.1K
In Vitro Thrombosis Test for Ventricular Assist Devices
09:15

In Vitro Thrombosis Test for Ventricular Assist Devices

Published on: March 21, 2025

1.2K

Area of Science:

  • Cardiology
  • Medical Devices
  • Heart Failure Management

Background:

  • Many heart failure patients continue cardiac resynchronization therapy (CRT) after continuous flow left ventricular assist device (CF-LVAD) implantation.
  • The clinical impact of continuing CRT in CF-LVAD patients remains under investigation.

Purpose of the Study:

  • To assess the impact of CRT on clinical outcomes in CF-LVAD patients.
  • To compare mortality, hospitalizations, and ventricular arrhythmia incidence between CF-LVAD patients with CRT-D and those with ICD alone.

Main Methods:

  • Multicenter study of 488 patients (265 CRT-D, 223 ICD alone) who underwent CF-LVAD implantation (2007-2015).
  • Analysis compared outcomes including mortality, hospitalizations, and ventricular arrhythmia incidence.
  • Kaplan-Meier analysis and multivariate Cox regression were used to evaluate survival benefits.

Main Results:

  • No significant difference in survival between CRT-D and ICD groups (log rank P=0.28).
  • No survival benefit observed with CRT-D versus ICD (P=0.16); amiodarone use increased mortality (HR 1.77, P=0.01).
  • No differences in all-cause or heart failure hospitalizations, ventricular arrhythmia incidence, or ICD shocks.
  • CRT-D group had significantly more pulse generator replacements (26% vs 15.5%, P=0.003).

Conclusions:

  • Continued CRT in CF-LVAD patients was not associated with improved survival or reduced hospitalizations.
  • CRT did not decrease ventricular arrhythmia incidence or ICD therapies in this cohort.
  • CRT was linked to a higher rate of pulse generator changes, indicating no added clinical benefit.