[The swelling behavior of choline fenofibrate hydrogel matrix tablets using dynamic image analysis].

Area of Science:

• Pharmaceutical Sciences
• Materials Science

Background:

• Hydrogel matrix tablets are crucial for controlled drug delivery.
• Understanding formulation effects on swelling is key to predicting drug release.

Purpose of the Study:

• To investigate formulation effects on choline fenofibrate hydrogel matrix tablet swelling.
• To correlate swelling properties with drug release profiles.
• To establish predictive models for hydrogel matrix tablet behavior.

Main Methods:

• Dynamic image analysis was used to evaluate swelling.
• Volume swelling ratio (SR) and height/width ratio (k) were key metrics.
• Hydroxypropyl methylcellulose (HPMC) concentration and K15M/K4M ratio were varied.

Main Results:

• HPMC amount and K15M/K4M ratio significantly influenced SR.
• All tested formulation factors affected k, indicating gel strength.
• Strong correlations were found between swelling parameters and drug release rates.

Conclusions:

• Formulation significantly dictates the swelling behavior of choline fenofibrate hydrogel matrix tablets.
• Swelling properties are reliable predictors of drug release.
• This study provides valuable insights for designing effective hydrogel matrix tablets.