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Updated: Feb 8, 2026

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness
05:51

Measuring the Carotid to Femoral Pulse Wave Velocity Cf-PWV to Evaluate Arterial Stiffness

Published on: May 3, 2018

18.6K

Arterial Stiffness in CKD: A Review

Raymond R Townsend1

  • 1Department of Medicine, Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA.

American Journal of Kidney Diseases : the Official Journal of the National Kidney Foundation
|June 18, 2018
PubMed

Insights

Arterial stiffness, measured by pulse wave velocity, is linked to worse outcomes in chronic kidney disease (CKD) patients. Understanding these links may lead to new treatments to improve vascular health in CKD.

Area of Science:

  • Cardiovascular Medicine
  • Nephrology
  • Biomedical Engineering

Background:

  • Arterial stiffness is a key factor in cardiovascular disease (CVD) and kidney disease progression.
  • Carotid-femoral pulse wave velocity (cf-PWV) is a validated measure of arterial stiffness.

Purpose of the Study:

  • To review the role of arterial stiffness and cf-PWV in patients with chronic kidney disease (CKD).
  • To examine the relationship between cf-PWV and longitudinal kidney and cardiovascular outcomes.

Main Methods:

  • Narrative review of a decade of research from the Chronic Renal Insufficiency Cohort (CRIC) study.
  • Analysis of cross-sectional and longitudinal data on cf-PWV and clinical outcomes.

Main Results:

  • Arterial stiffness measures, particularly cf-PWV, are independently associated with adverse outcomes in CKD.
  • cf-PWV measurements demonstrate reproducibility and have identifiable determinants.

Conclusions:

  • Arterial stiffness is a significant contributor to understanding CVD mechanisms, kidney disease progression, and mortality in CKD.
  • Future interventions targeting vascular destiffening hold promise for improving outcomes in CKD patients.

Keywords:
Arterial stiffnessChronic Renal Insufficiency Cohort (CRIC)cardiovascular disease (CVD)chronic kidney disease (CKD)heart failure (HF)hypertensionkidney disease progressionmortalitypulse wave velocity (PWV)review

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