Related Experiment Video
Updated: Feb 8, 2026
03:22
Local Anesthetic Thoracoscopy for Undiagnosed Pleural Effusion
Published on: November 10, 2023
1.6K
Development and validation of response markers to predict survival and pleurodesis success in patients with malignant
Ioannis Psallidas1, Nikolaos I Kanellakis1, Stephen Gerry2
1Oxford Centre for Respiratory Medicine, Churchill Hospital, Oxford University Hospitals NHS Foundation Trust, Oxford, UK; Laboratory of Pleural and Lung Cancer Translational Research, Nuffield Department of Medicine, University of Oxford, Oxford, UK; Oxford Respiratory Trials Unit, Nuffield Department of Medicine, University of Oxford, Oxford, UK.
The Lancet. Oncology
|June 18, 2018
Summary
The PROMISE score, combining clinical and biological factors, accurately predicts 3-month mortality in malignant pleural effusion patients. This validated tool aids in treatment planning and prognosis assessment.
Area of Science:
- Oncology
- Pulmonology
- Biomarker Discovery
Background:
- Malignant pleural effusion (MPE) prevalence is rising globally.
- Prognostic biomarkers for MPE treatment planning and disease progression are lacking.
Purpose of the Study:
- Discover, validate, and assess biomarkers for survival and pleurodesis response in MPE.
- Develop a predictive score for MPE survival.
Main Methods:
- Utilized five independent datasets from randomized controlled trials.
- Mass spectrometry identified differential protein expression in pleural fluid.
- Developed a predictive model for 3-month mortality using clinical, radiological, and biological variables via least absolute shrinkage and selection operator regression.
Main Results:
- Identified 17 survival and 7 pleurodesis biomarker candidates.
- Gelsolin, MIF, versican, and TIMP1 accurately predicted survival; pleurodesis biomarkers failed validation.
- Developed the PROMISE score using eight variables, achieving strong discrimination in internal (C-statistic 0.78) and external (C-statistic 0.89) validation.
Conclusions:
- The PROMISE score is the first prospectively validated prognostic model for MPE.
- It integrates biological and clinical parameters to estimate 3-month mortality.
- The score is robust, clinically relevant, and can guide management strategies.
More Related Videos
Related Concept Videos
01:25Pleural Effusion I: Introduction
4.4K
Pleural effusion is an abnormal fluid accumulation in the pleural cavity, a narrow space between the lungs and the chest wall. It is not a disease per se but rather a symptom or indication of an underlying disease. In normal circumstances, this space contains a small amount of fluid (5 to 15 mL), a lubricant facilitating the non-frictional movement of the pleural surfaces.
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
There are two main types of pleural effusion: transudative and exudative. They are differentiated using Light's...
4.4K
01:28Pleural Effusion II: Symptoms and Management
803
Pleural Effusion Overview
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
A pleural effusion is the abnormal collection of fluid between the parietal and visceral pleura layers of tissue that form the lining of the lungs and chest cavity. It can occur independently or due to surrounding parenchymal diseases, such as infection, malignancy, or inflammatory conditions.
Clinical Manifestations:
803
01:29Reliability and Validity
14.1K
Reliability and validity are two important considerations that must be made with any type of data collection. Reliability refers to the ability to consistently produce a given result. In the context of psychological research, this would mean that any instruments or tools used to collect data do so in consistent, reproducible ways.
14.1K
02:17Ecological Succession
21.6K
Ecological succession is influenced by the processes of facilitation, inhibition, and toleration. Facilitation occurs when early successional species create more favorable ecological conditions for subsequent species, such as enhanced nutrient, water, or light availability. In contrast, inhibition happens when early successional species create unfavorable ecological conditions for potential successive species, such as limiting resource availability. In some cases, later successional species...
21.6K
01:18Introduction To Survival Analysis
811
Survival analysis is a statistical method used to study time-to-event data, where the "event" might represent outcomes like death, disease relapse, system failure, or recovery. A unique feature of survival data is censoring, which occurs when the event of interest has not been observed for some individuals during the study period. This requires specialized techniques to handle incomplete data effectively.
The primary goal of survival analysis is to estimate survival time—the time...
The primary goal of survival analysis is to estimate survival time—the time...
811
01:20Comparing the Survival Analysis of Two or More Groups
609
Survival analysis is a cornerstone of medical research, used to evaluate the time until an event of interest occurs, such as death, disease recurrence, or recovery. Unlike standard statistical methods, survival analysis is particularly adept at handling censored data—instances where the event has not occurred for some participants by the end of the study or remains unobserved. To address these unique challenges, specialized techniques like the Kaplan-Meier estimator, log-rank test, and...
609