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Related Concept Videos

lncRNA - Long Non-coding RNAs02:39

lncRNA - Long Non-coding RNAs

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In humans, more than 80% of the genome gets transcribed. However, only around 2% of the genome codes for proteins. The remaining part produces non-coding RNAs which includes ribosomal RNAs, transfer RNAs, telomerase RNAs, and regulatory RNAs, among other types. A large number of regulatory non-coding RNAs have been classified into two groups depending upon their length – small non-coding RNAs, such as microRNA, which are less than 200 nucleotides in length, and long non-coding RNA...
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Small interfering RNAs, or siRNAs, are short regulatory RNA molecules that can silence genes post-transcriptionally, as well as the transcriptional level in some cases. siRNAs are important for protecting cells against viral infections and silencing transposable genetic elements.
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piRNA - Piwi-interacting RNAs02:57

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PIWI-interacting RNAs, or piRNAs, are the most abundant short non-coding RNAs. More than 20,000 genes have been found in humans that code for piRNAs while only 2000 genes have been found for miRNAs. piRNAs can act at the transcriptional and post-transcriptional levels and have a vital role in silencing transposable elements present in germ cells. They are also involved in epigenetic silencing and activation. Previously, they were thought to function only in germ cells but new evidence suggests...
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The Nursing Code of Ethics sets the ethical benchmark for the profession, and guides nurses in ethical analysis and decision making at the societal, organizational, and clinical levels. The code encompasses showing compassion and respect for the patient, their families, and communities in all circumstances while committing to providing patient-centered care. In addition, the code states that nurses must advocate for the patient by defending a cause or recommendation to protect their rights,...
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An aortic aneurysm is a localized outpouching or dilation at a weak point in the artery wall. It may involve different parts of the aorta, such as the abdominal aorta, aortic arch, or thoracic aorta.Etiological factorsSeveral disorders are associated with aortic aneurysms.Congenital causes, such as primary connective tissue disorders like Marfan syndrome, impact the integrity and strength of connective tissues, notably affecting the aorta. Marfan syndrome is a genetic disorder that specifically...
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Updated: Feb 8, 2026

Quantitative Micro-CT Analysis of Aortopathy in a Mouse Model of &#946;-aminopropionitrile-induced Aortic Aneurysm and Dissection
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Non-coding RNAs in aneurysmal aortopathy.

Joshua M Spin1, Daniel Y Li2, Lars Maegdefessel3

  • 1Cardiovascular Medicine and Stanford Cardiovascular Institute, Stanford University School of Medicine, Stanford, CA, USA; VA Palo Alto Health Care System, 3801 Miranda Avenue, Palo Alto, CA, USA.

Vascular Pharmacology
|June 18, 2018
PubMed
Summary
This summary is machine-generated.

Non-coding RNAs, including microRNAs and long-non-coding RNAs, are key regulators in the development of aortic aneurysms. Understanding their role offers potential new therapeutic targets for this serious public health condition.

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Area of Science:

  • Cardiovascular Research
  • Molecular Biology
  • Genetics

Background:

  • Aortic aneurysms are a significant health issue with no current medical treatments.
  • Their development involves complex, multifactorial changes in the aortic wall, including smooth muscle and endothelial dysfunction, extracellular matrix remodeling, and inflammation.
  • These changes lead to aortic dilation, rupture, and dissection, causing high mortality.

Purpose of the Study:

  • To review current knowledge on the role of non-coding RNAs in aneurysmal aortopathies.
  • To highlight non-coding RNAs as potential therapeutic targets for aortic aneurysm prevention and treatment.

Main Methods:

  • Literature review of studies investigating non-coding RNAs in aortic aneurysm development.
  • Focus on both microRNAs and long-non-coding RNAs.

Main Results:

  • Non-coding RNAs are identified as critical regulators in the pathogenesis of aortic aneurysms in humans and animal models.
  • While microRNAs have been extensively studied, long-non-coding RNAs are emerging as significant players.

Conclusions:

  • Non-coding RNAs are integral to the development and progression of aortic aneurysms.
  • Targeting non-coding RNAs presents a promising future strategy for managing aneurysmal aortopathies.