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Changes in the breath sound spectrum with bronchodilation in children with asthma

Mariko Nukaga1, Hideyuki Tabata1, Mayumi Enseki1

  • 1Department of Pediatrics, Tokai University School of Medicine, Japan.

Respiratory Investigation
|June 18, 2018
PubMed

Insights

Breath sound spectrum curve indices show significant changes after bronchodilator use in children with asthma. These parameters may help assess bronchial reversibility, offering new biomarkers for airway function.

Area of Science:

  • Pediatric Pulmonology
  • Respiratory Medicine
  • Biomarkers

Background:

  • Breath sound parameters are emerging as potential biomarkers for assessing airway function in asthma.
  • Understanding airway function in pediatric asthma is crucial for effective management.

Purpose of the Study:

  • To investigate the impact of bronchodilation on various breath sound parameters in children with asthma.
  • To evaluate the potential of these parameters as indicators of bronchial reversibility.

Main Methods:

  • Sixty-four children with asthma underwent breath sound analysis before and after administration of a short-acting beta-agonist.
  • Breath sound parameters included frequency limiting (F50, F99), roll-off (slope), and spectrum curve indices (P3/PT, P4/PT, A3/AT, B4/AT, RPF75, RPF50).
  • Lung function was assessed using spirometry and the forced oscillation technique (FOT).

Main Results:

  • Spectrum curve indices (A3/AT, B4/AT, RPF75, RPF50) significantly increased post-bronchodilation.
  • Increased RPF50 correlated with decreased resistance difference (R5-R20) measured by FOT.
  • Changes in A3/AT and B4/AT positively correlated with changes in forced expiratory volume in one second (FEV1).

Conclusions:

  • Spectrum curve indices effectively indicate bronchodilation in children with asthma.
  • These breath sound parameters show promise for assessing bronchial reversibility.
  • Breath sound analysis offers a non-invasive tool for evaluating airway function in pediatric asthma.
Abstract

Keywords:
AsthmaBreath sound analysisBronchial reversibilityChildrenβ(2)-agonist

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