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Catheter-based closure of the patent ductus arteriosus in lower weight infants

Leeann R Pavlek1, Jonathan L Slaughter2, Darren P Berman3

  • 1Center for Perinatal Research, Nationwide Children's Hospital, Columbus, OH.

Seminars in Perinatology
|June 18, 2018
PubMed

Insights

Catheter-based closure is a feasible option for patent ductus arteriosus (PDA) in infants under 6kg. However, more comparative trials are needed to determine the best strategy for closing this condition in smaller infants.

Area of Science:

  • Cardiology
  • Pediatric Cardiology
  • Interventional Cardiology

Background:

  • Traditional treatments for patent ductus arteriosus (PDA) like drug therapy and surgical ligation carry risks.
  • Catheter-based PDA closure is the standard for adults and larger infants (≥6kg).
  • Growing interest exists in applying catheter-based closure to lower-weight infants (<6kg).

Purpose of the Study:

  • To review catheter-based PDA closure in infants weighing less than 6kg.
  • To assess procedural feasibility, safety, and efficacy.
  • To identify gaps in current research for this patient subgroup.

Main Methods:

  • Literature review of catheter-based PDA closure techniques and devices.
  • Analysis of technical success rates and safety profiles.
  • Evaluation of the quality of evidence regarding procedural efficacy.

Main Results:

  • Catheter-based PDA closure is technically feasible in infants weighing less than 6kg.
  • The safety profile and efficacy require further investigation through comparative studies.
  • Current evidence is insufficient to establish this as the optimal closure strategy for this group.

Conclusions:

  • Catheter-based PDA closure shows promise for infants under 6kg.
  • Comparative trials are essential to determine the optimal ductal closure strategy in this vulnerable population.
  • Further research is needed to refine techniques and evaluate long-term outcomes.

Keywords:
PDA ligationcardiac catheterizationpatent ductus arteriosuspremature infant

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