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Regulation of prostate cancer by hormone-responsive G protein-coupled receptors

Wei Wang1, Zhao-Xia Chen1, Dong-Yu Guo1

  • 1Department of Clinical Laboratory, Xiamen Huli Guoyu Clinic, Co., Ltd., Xiamen, China.

Pharmacology & Therapeutics
|June 18, 2018
PubMed

Insights

G protein-coupled receptors (GPCRs) regulate prostate cancer. Targeting reproductive function-mediating GPCRs offers new therapeutic strategies for prostate cancer treatment.

Area of Science:

  • Endocrinology
  • Oncology
  • Pharmacology

Background:

  • Prostate cancer progression is linked to androgen and androgen receptor (AR) signaling.
  • AR antagonists and steroidogenic enzyme inhibitors are established therapeutic strategies.
  • G protein-coupled receptors (GPCRs) are crucial regulators of physiological processes and drug targets.

Purpose of the Study:

  • To review the role of GPCRs in prostate cancer regulation.
  • To highlight specific GPCRs involved in prostate cancer, including those mediating reproductive functions.
  • To summarize potential therapeutic strategies targeting GPCRs for prostate cancer treatment.

Main Methods:

  • Literature review focusing on GPCRs and prostate cancer.
  • Identification of GPCRs involved in reproductive functions and their link to prostate cancer.
  • Summary of current and emerging therapeutic approaches targeting GPCRs.

Main Results:

  • Several GPCRs, including gonadotropin-releasing hormone receptor, luteinizing hormone receptor, follicle-stimulating hormone receptor, relaxin receptor, ghrelin receptor, and kisspeptin receptor, are implicated in prostate cancer.
  • These GPCRs play a regulatory role in prostate cancer development and progression.
  • Targeting these GPCRs presents novel therapeutic opportunities.

Conclusions:

  • GPCRs represent a significant regulatory network in prostate cancer.
  • Targeting specific GPCRs involved in reproductive functions offers promising avenues for novel prostate cancer therapies.
  • Further research into GPCR-targeted therapies could lead to improved treatment outcomes.
Keywords:
Androgen receptorCastration resistanceG protein-coupled receptorsProstate cancerReproduction

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