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HIV and Aging - Perhaps Not as Dramatic as We Feared?
Tanja Engel1, Marieke Raffenberg1, Catia Marzolini2
1University Department of Medicine and Infectious Diseases Service, Kantonsspital Baselland, University of Basel, Bruderholz, Switzerland.
Gerontology
|June 18, 2018
Summary
Highly active antiretroviral therapy (ART) for HIV may not cause as many aging-related health issues as once thought. Recent data suggests the problem of morbidity in HIV patients might be less severe than previously believed.
Area of Science:
- Infectious Diseases
- Gerontology
- Metabolic Disorders
Background:
- Highly active antiretroviral therapy (ART) introduced in 1995 is linked to metabolic complications in HIV patients.
- Increased rates of myocardial infarction, renal insufficiency, neurocognitive dysfunction, and fractures are reported in HIV-positive individuals.
- Chronic inflammation despite HIV suppression may contribute to these complications.
Purpose of the Study:
- To review recent data on aging-related morbidity in HIV.
- To evaluate if the problem of aging-related health issues in HIV is as severe as previously believed.
Main Methods:
- This is a viewpoint paper.
- It summarizes and examines recent scientific data.
Main Results:
- The paper examines the possibility that aging-related morbidity in HIV may not be as dramatic as previously believed.
- Recent data is reviewed to assess the severity of these complications.
Conclusions:
- The actual impact of HIV and its treatment on aging-related morbidity requires further nuanced evaluation.
- The severity of metabolic complications and other age-related issues in HIV-positive individuals may be overestimated.
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