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Related Experiment Video

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Neutrophil Extracellular Traps: How to Generate and Visualize Them
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Neutrophil Extracellular Traps in the Second Decade.

Volker Brinkmann

    Journal of Innate Immunity
    |June 18, 2018
    PubMed
    Summary

    Neutrophil extracellular traps (NETs) are crucial immune cells initially thought to fight microbes. Now, their roles in inflammation and thrombosis are recognized, impacting health and disease.

    Area of Science:

    • Immunology
    • Pathophysiology

    Background:

    • Neutrophil extracellular traps (NETs) were first described nearly 15 years ago.
    • Initially, NETs were understood as a component of the innate immune system for combating pathogens.

    Purpose of the Study:

    • To provide a concise overview of the diverse functions of NETs in both health and disease.
    • To highlight the expanding knowledge of NETs beyond their antimicrobial roles.

    Main Methods:

    • This is a review article, synthesizing existing research on NETs.
    • The review covers the evolution of understanding NETs over the past 15 years.

    Main Results:

    • NETs possess far-reaching capabilities beyond microbial defense.
    • They are implicated in various pathophysiological processes, including inflammation and thrombosis.
    Keywords:
    AutoimmunityBacterial infectionCancerCoagulationExtracellular trapsInflammation

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  • The function of NETs is context-dependent, beneficial when timely and localized, but detrimental when dysregulated.

    • Conclusions:

    • NETs play complex roles in health and disease.
    • Imbalances in NET generation or clearance can lead to adverse health outcomes.
    • Further understanding of NET regulation is critical for managing diseases involving these structures.