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Related Concept Videos

Schizophrenia01:17

Schizophrenia

998
Schizophrenia, a term introduced by Swiss psychiatrist Eugen Bleuler in 1911, describes a severe psychological disorder marked by profound disruptions in attention, thought processes, language, emotion, and interpersonal relationships. The core feature of schizophrenia is psychosis — a state characterized by a fundamental detachment from reality. This disconnection manifests through distorted logic, impaired perception, and atypical behavior, severely affecting the lives of those...
998
Biological Causes of Schizophrenia01:29

Biological Causes of Schizophrenia

644
Schizophrenia, a severe psychiatric disorder, arises from a complex interplay of biological factors, including genetic predisposition, structural brain abnormalities, neurotransmitter dysregulation, and developmental irregularities. These factors collectively contribute to the onset and progression of the disorder, which typically manifests in late adolescence or early adulthood.
Genetic Factors in Schizophrenia
The genetic basis of schizophrenia is strongly supported by family and twin...
644
Strategies for Assessing and Addressing Confounding01:25

Strategies for Assessing and Addressing Confounding

416
Confounding is a critical issue in epidemiological studies, often leading to misleading conclusions about associations between exposures and outcomes. It occurs when the relationship between the exposure and the outcome is mixed with the effects of other factors that influence the outcome. Given that, addressing confounding is of high importance for drawing accurate inferences in research.
Confounding can be addressed at both the design phase of a study and through analytical methods after data...
416
Psychological and Sociocultural Causes of Schizophrenia01:29

Psychological and Sociocultural Causes of Schizophrenia

635
Schizophrenia, a complex psychiatric disorder, has been historically misunderstood. Early psychological theories attributed its origins to childhood trauma and unresponsive parenting. However, contemporary research largely rejects these notions, favoring the vulnerability-stress hypothesis. This model proposes that individuals with a genetic predisposition to schizophrenia may develop the disorder following exposure to significant environmental stressors. Notably, studies on high-risk...
635
Negative and Cognitive Symptoms of Schizophrenia01:30

Negative and Cognitive Symptoms of Schizophrenia

604
Negative symptoms of schizophrenia indicate a reduction or absence of typical behaviors and emotional responses found in healthy individuals, while positive symptoms reflect an excess or distortion of normal functioning.
Negative Symptoms
Negative symptoms of schizophrenia manifest as deficits in normal emotional and behavioral functioning, profoundly impacting daily life. Individuals with schizophrenia often display a flat affect, characterized by a near-total absence of emotional expression,...
604
Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders01:27

Psychosis: Pathophysiology of Schizophrenia and Other Psychotic Disorders

2.0K
Schizophrenia is a neurodevelopmental disorder whose origins are rooted in complex genetic components. Despite our burgeoning understanding, the pathophysiology of this disorder remains incompletely deciphered.
Researchers have identified genetic factors that increase susceptibility to schizophrenia, underscoring the intricate interplay between genetics and environment in disease development. At the core of schizophrenia's pathophysiology is excessive dopaminergic neurotransmission within...
2.0K

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Relationship between clinical outcomes measures and personal and social performance functioning in a prospective, interventional study in schizophrenia.

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The impact of thought disorder on therapeutic alliance and personal recovery in schizophrenia and schizoaffective disorder: An exploratory study.

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Treatment response, safety, and tolerability of paliperidone extended release treatment in patients recently diagnosed with schizophrenia.

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Symptom control, functioning and satisfaction among Swiss patients treated with risperidone long-acting injectable.

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Is living with psychosis demoralizing? Insight, self-stigma, and clinical outcome among people with schizophrenia across 1 year.

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Related Experiment Video

Updated: Feb 8, 2026

A Strategy to Identify de Novo Mutations in Common Disorders such as Autism and Schizophrenia
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[Addressing maladherence in schizophrenia].

Roland Vauth1

  • 11 Universitäre Psychiatrische Kliniken Basel, Basel.

Therapeutische Umschau. Revue Therapeutique
|June 19, 2018
PubMed
Summary

Maladaptive behaviors in schizophrenia significantly contribute to relapses. A four-level framework is proposed to tailor interventions, focusing on motivation and attitudes to improve treatment adherence.

Area of Science:

  • Psychiatry
  • Clinical Psychology
  • Neuroscience

Background:

  • Maladaptive behavior is a critical factor in schizophrenia, leading to detrimental relapses.
  • Current care often overlooks motivational aspects, impacting treatment adherence.
  • Relapses in schizophrenia can be demoralizing for patients.

Purpose of the Study:

  • To present a conceptual four-level framework for addressing maladaptive behavior in schizophrenia.
  • To promote more effective, individually tailored adherence strategies.
  • To prevent the negative impact of insight without addressing motivational deficits.

Main Methods:

  • Empirical evidence is reviewed and organized into a four-level framework.
  • The framework includes functional analysis of maladaptive behavior.

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  • It also addresses dysfunctional attitudes toward the disorder and its treatment.

    • Main Results:

    • A structured, four-level approach to understanding and intervening in maladaptive behavior is proposed.
    • The framework facilitates individually tailored interventions for schizophrenia patients.
    • It emphasizes motivational processes and dysfunctional attitudes.

    Conclusions:

    • A tailored, four-level framework can enhance treatment adherence in schizophrenia.
    • Addressing motivational processes and dysfunctional attitudes is crucial for managing maladaptive behavior.
    • This approach aims to prevent relapses and improve patient outcomes.