Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

What is Genetic Engineering?00:49

What is Genetic Engineering?

80.3K
Overview
80.3K
Overview of Cell-Matrix Interactions01:24

Overview of Cell-Matrix Interactions

9.1K
The extracellular matrix or ECM holds cells together to form a tissue and allows the cells within the tissue to communicate. ECM comprises proteins such as fibronectin, collagen, laminin, etc. The most abundant protein in this space is collagen. Collagen fibers are interwoven with carbohydrate-containing protein molecules called proteoglycans. ECM allows cell migration and provides a structural scaffold at cell adhesion that anchors the cell when the extracellular matrix proteins interact with...
9.1K
Chemistry of the Cell02:58

Chemistry of the Cell

48.1K
The cell is chemically composed of water, organic molecules and inorganic ions.
Water
The polarity of the water molecule and its resulting hydrogen bonding makes water a unique substance with special properties that are intimately tied to the processes of life. Life originally evolved in an aqueous environment, and most of an organism’s cellular chemistry and metabolism occur inside the aqueous contents of the cell’s cytoplasm. Special properties of water are its high heat capacity...
48.1K
Genetics of Speciation02:16

Genetics of Speciation

21.7K
Speciation is the evolutionary process resulting in the formation of new, distinct species—groups of reproductively isolated populations.
21.7K
Introduction to Membrane Proteins01:16

Introduction to Membrane Proteins

81.4K
The cell membrane, or plasma membrane, is an ever-changing landscape. It is described as a fluid mosaic where various macromolecules are embedded in the phospholipid bilayer. Among the macromolecules are proteins. The protein content varies across cell types. For example, mitochondrial inner membranes contain ~76% protein content, while myelin contains ~18% protein content. Individual cells contain many types of membrane proteins—red blood cells contain over 50—and different cell...
81.4K
What is Population Genetics?01:25

What is Population Genetics?

64.8K
A population is composed of members of the same species that simultaneously live and interact in the same area. When individuals in a population breed, they pass down their genes to their offspring. Many of these genes are polymorphic, meaning that they occur in multiple variants. Such variations of a gene are referred to as alleles. The collective set of all the alleles within a population is known as the gene pool.
64.8K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

T-cell Receptor (TCR) Targeting with Multivalent T-cell Engagers.

bioRxiv : the preprint server for biology·2026
Same author

Outcomes of hemophagocytic lymphohistiocytosis in acute myeloid leukemia: the 3-site Mayo Clinic experience.

Blood neoplasia·2026
Same author

One vs. 2 vs. ≥3 TET2 mutations in chronic myelomonocytic leukemia: co-mutation patterns and prognostic relevance in the context of contemporary prognostic models including BLAST-mol and CPSS-mol.

Blood cancer journal·2026
Same author

Rapid germ line testing with hair root bulb-derived DNA for hereditary predisposition and inherited marrow failure states.

Blood advances·2026
Same author

Male-biased Yap1-Cd276/B7-H3 axis for immune evasion in medulloblastoma.

Cancer cell·2026
Same author

Incorporation of Genomic Determinants Improves Diagnostic Accuracy of Oligomonocytic Chronic Myelomonocytic Leukemia.

Blood cancer discovery·2026

Related Experiment Video

Updated: Feb 8, 2026

Engineering Cell-permeable Protein
21:08

Engineering Cell-permeable Protein

Published on: December 28, 2009

15.0K

Programming Cell-Cell Interactions through Non-genetic Membrane Engineering.

Clifford M Csizmar1, Jacob R Petersburg1, Carston R Wagner1

  • 1Department of Medicinal Chemistry, University of Minnesota, Minneapolis, MN 55455, USA.

Cell Chemical Biology
|June 19, 2018
PubMed
Summary

Non-genetic cell membrane engineering offers a versatile alternative to genetic modification for cell therapies. These methods enable targeted cell-cell interactions, expanding applications in regenerative medicine and immunotherapy.

Keywords:
cell-cell interactionsimmunotherapyintercellularlipidmembrane engineeringtissue engineering

More Related Videos

Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria
06:08

Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria

Published on: January 25, 2019

13.6K
A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts
08:43

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

Published on: December 1, 2018

12.0K

Related Experiment Videos

Last Updated: Feb 8, 2026

Engineering Cell-permeable Protein
21:08

Engineering Cell-permeable Protein

Published on: December 28, 2009

15.0K
Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria
06:08

Genetic Engineering of Dictyostelium discoideum Cells Based on Selection and Growth on Bacteria

Published on: January 25, 2019

13.6K
A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts
08:43

A Fluorescence Fluctuation Spectroscopy Assay of Protein-Protein Interactions at Cell-Cell Contacts

Published on: December 1, 2018

12.0K

Area of Science:

  • Biotechnology
  • Cell Biology
  • Regenerative Medicine

Background:

  • Genetic engineering for cell therapies has limitations, including applicability to all cell types and permanent modifications.
  • Non-genetic cell membrane modification is gaining interest for enabling targeted cell-cell interactions.
  • Existing non-genetic methods are not widely applied to direct specific cell-cell interactions.

Purpose of the Study:

  • To review non-genetic cell membrane engineering approaches for targeted intercellular interactions.
  • To summarize the applications of these non-genetic methods.
  • To provide perspective on clinical translation potential.

Main Methods:

  • Hydrophobic membrane insertion
  • Chemical modification
  • Liposome fusion
  • Metabolic engineering
  • Enzymatic remodeling

Main Results:

  • Detailed review of various non-genetic membrane engineering techniques.
  • Summary of major applications for each technique.
  • Analysis of ideal features for clinical translation.

Conclusions:

  • Non-genetic cell membrane engineering provides a promising alternative to genetic modification for cell therapies.
  • These approaches can overcome limitations of genetic engineering, enabling broader applications.
  • Further development is needed to optimize these systems for clinical translation.