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Related Experiment Video

Updated: Feb 8, 2026

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Olfactory Context Dependent Memory: Direct Presentation of Odorants

Published on: September 18, 2018

A Visual-Cue-Dependent Memory Circuit for Place Navigation.

Han Qin¹, Ling Fu², Bo Hu³

¹Brain Research Center and State Key Laboratory of Trauma, Burns, and Combined Injury, Third Military Medical University, Chongqing 400038, China; Britton Chance Center for Biomedical Photonics, Wuhan National Laboratory for Optoelectronics-Huazhong University of Science and Technology, Key Laboratory for Biomedical Photonics of Ministry of Education, School of Engineering Sciences, Huazhong University of Science and Technology, Wuhan 430074, China.

|June 19, 2018

Summary

This summary is machine-generated.

Survival depends on remembering safe places. This study found that persistent-task-associated activity in the medial entorhinal cortex (MEC) layer II-dentate gyrus circuit is crucial for visually guided navigation in mice.

Keywords:

axonal projection dentate gyrus fiber photometry hippocampus medial entorhinal cortex navigation persistent activity spatial memory

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Integrating Visual Psychophysical Assays within a Y-Maze to Isolate the Role that Visual Features Play in Navigational Decisions

Integrating Visual Psychophysical Assays within a Y-Maze to Isolate the Role that Visual Features Play in Navigational Decisions

Published on: May 2, 2019

Area of Science:

Neuroscience
Cognitive Science
Systems Neuroscience

Background:

Place navigation is essential for survival and relies on medial entorhinal cortex (MEC)-hippocampal circuits.
Learning-dependent neural activity changes within these circuits are not well understood.

Purpose of the Study:

To investigate experience-dependent changes in neuronal activity within distinct MEC-hippocampal pathways during navigation tasks.
To identify the neural circuits critical for learning and remembering navigation routes.

Main Methods:

Optic fiber photometry was used to record neuronal activity in freely behaving mice.
Optogenetic suppression was employed to assess the causal role of specific neural pathways.

Main Results:

A persistent-task-associated (PTA) activity was discovered, dependent on learned visual cues.
This PTA activity was selectively induced in the MEC layer II-dentate gyrus pathway, not in the MEC layer III-CA1 pathway.
Optogenetic suppression of this activity impaired navigation to the target location.

Conclusions:

The visual system, MEC layer II, and dentate gyrus form essential hubs in a memory circuit for visually guided navigation.
Experience-dependent plasticity in the MEC layer II-dentate gyrus pathway is critical for spatial memory and navigation.