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Some individuals interpret life events as a consequence of their personal choices and actions, while others believe that outcomes are dictated by fate or destiny. This divergence in perspective has been examined in psychological and cross-cultural studies, particularly in relation to religious faith and cultural beliefs about causality.Fate and Personal ResponsibilityPeople who emphasize personal responsibility view events as direct consequences of their decisions. For instance, breaking a leg...
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Related Experiment Video

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Long-term Live-cell Imaging to Assess Cell Fate in Response to Paclitaxel
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Modulating Cell Fate as a Therapeutic Strategy.

Brian Lin1, Priya Srikanth2, Alison C Castle2

  • 1Center for Regenerative Medicine, Massachusetts General Hospital, 185 Cambridge Street, Boston, MA 02114, USA; Harvard Stem Cell Institute, Cambridge, MA 02138, USA.

Cell Stem Cell
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Cell fate plasticity allows cells to change their identity, aiding tissue repair or causing disease. Understanding and manipulating this plasticity could lead to new regenerative therapies.

Keywords:
cell plasticitydedifferentiationregenerationregenerative medicine

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Area of Science:

  • Cellular biology
  • Regenerative medicine
  • Pathology

Background:

  • Tissue regeneration often involves cell fate plasticity, where cells alter their lineage.
  • This cellular plasticity can be a natural repair mechanism or contribute to disease progression.

Purpose of the Study:

  • To summarize examples of physiological and aberrant cellular plasticity.
  • To explore enhancing endogenous plasticity for regenerative therapies and reversing pathologic plasticity.

Main Methods:

  • Review and synthesis of existing literature on cell fate plasticity.
  • Illustrative examples of cellular plasticity in regeneration and disease.

Main Results:

  • Cell fate plasticity is a key feature in both tissue repair and pathologic transformations.
  • Enhancing endogenous plasticity presents a potential therapeutic strategy.

Conclusions:

  • Targeting cell fate modulation offers a novel approach for regenerative medicine.
  • Further research into controlling cellular plasticity is warranted for therapeutic applications.