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Normal reference ranges for aortic diameters in preterm infants
Lulu Abushaban1,2, Thinakar Vel Mariappa1, Jebaraj Rathinasamy1
1Chest Diseases Hospital, Ministry of Health, Kuwait City, KuwaitaKuwait.
Insights
This study establishes normal reference ranges and Z-scores for aortic diameters in preterm infants. These findings correlate aortic measurements with body surface area, aiding in clinical assessment.
Area of Science:
- Neonatal Cardiology
- Pediatric Echocardiography
- Growth and Development
Background:
- Accurate assessment of aortic diameters is crucial for preterm infants.
- Establishing normative data is essential for identifying potential cardiovascular abnormalities.
- Previous studies may lack comprehensive data specific to preterm populations.
Purpose of the Study:
- To determine normal reference ranges and Z-scores for aortic diameters in preterm infants.
- To evaluate the correlation of aortic diameters with body surface area, body weight, and gestational age.
- To provide a valuable reference tool for clinicians assessing preterm infants.
Main Methods:
- A prospective study included 268 preterm infants.
- Echocardiograms measured ascending aorta, transverse aorta, and aortic isthmus diameters.
- Measurements were taken from birth up to 36 weeks postmenstrual age, with body surface area categorized into 13 groups.
Main Results:
- Aortic diameters showed significant correlations with body weight and body surface area.
- Normal reference ranges and Z-scores were established based on body surface area.
- A progressive increase in aortic diameters was observed with increasing body surface area and during the first 9 weeks of life.
Conclusions:
- Ascending aorta, transverse aorta, and aortic isthmus diameters are significantly correlated with body surface area and weight in preterm infants.
- The study provides essential reference data and Z-scores for these aortic segments.
- This data serves as a normal reference tool for clinical use in preterm infant cardiology.
Objective:
To establish normal reference ranges and Z-scores for aortic diameters in preterm infants according to the body surface area and assess their correlation with body weight, body surface area, and gestational age.
Patients And Methods:
In a prospective study, 268 preterm infants who fulfilled the criteria for inclusion were examined. Echocardiograms were performed to measure the ascending aorta, transverse aorta, and aortic isthmus diameters on 0 days to 6 days of life and at weekly intervals until the babies reached 36 weeks. Body surface area was divided into 13 groups from 0.07 m2 to 0.19 m2.
Results:
The mean gestational age was 29.8 [± 2.38 standard deviation (SD)] weeks, ranging from 24 weeks to 35 weeks. The mean body weight was 1479 (± 413 SD) g, ranging from 588 g to 3380 g, and the mean body surface area was 0.13 m2, ranging from 0.07 m2 to 0.19 m2. All the aortic diameters correlated well with both body weight and body surface area. Reference ranges with the mean ± SD, range, and Z-scores were calculated for aortic diameters according to the body surface area. A significant gradual increase was observed in ascending aorta, transverse aorta, and aortic isthmus diameters with increasing body surface area. Overall, a progressive and significant increase in ascending aorta, transverse aorta, and aortic isthmus diameters was observed during the first 9 weeks of life.
Conclusion:
The ascending aorta, transverse aorta, and aortic isthmus diameters exhibited a significant correlation with the body surface area and body weight. This study provides reference data with Z-scores that can be used as a normal reference tool for the ascending aorta, transverse aorta, and aortic isthmus diameters for preterm infants based on the body surface area.
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