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Health risks associated with genetic alterations in internal clock system by external factors
Suliman Khan1,2,3, Ghulam Nabi1,3, Lunguang Yao2
1The Key Laboratory of Aquatic Biodiversity and Conservation of Chinese Academy of Sciences, Institute of Hydrobiology, Chinese Academy of Sciences, Wuhan, Hubei, 430072, P.R China.
International Journal of Biological Sciences
|June 19, 2018
Summary
Disrupted circadian rhythms and sleep, influenced by environmental factors, negatively impact health. Understanding clock gene function is crucial for preventing disorders like cancer and heart disease.
Area of Science:
- Chronobiology
- Environmental Health
- Genetics
Background:
- The circadian system regulates physiological and behavioral processes, crucial for organismal health.
- Circadian rhythm and sleep are interconnected, influenced by environmental factors.
- Disruptions to these rhythms can lead to various health disorders.
Purpose of the Study:
- To review the impact of environmental factors on the circadian system and sleep.
- To identify risks and factors associated with circadian disruption.
- To highlight the link between circadian disruption and health disorders.
Main Methods:
- Literature review focusing on circadian rhythm, sleep, and environmental influences.
- Analysis of studies investigating clock gene function and its disruption.
- Identification of pathways implicated in health disorders linked to circadian disruption.
Main Results:
- Environmental variations significantly affect clock gene functionality and circadian rhythm.
- Disrupted circadian rhythm and sleep are linked to increased risk of cancer, depression, and cardiac disorders.
- Specific risks and associated factors contributing to circadian system disruption were identified.
Conclusions:
- Circadian system integrity is vital for maintaining health.
- Environmental factors play a critical role in regulating circadian rhythms and sleep.
- Further research into the pathways affected by circadian disruption is essential for developing preventative strategies against life-threatening disorders.
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