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Cryptococcal meningoencephalitis in patients with mantle cell lymphoma on ibrutinib
Kai Sun1, Saro Kasparian1, Swaminathan Iyer2
1Department of Medicine, Houston Methodist Hospital, Houston, TX 77030, USA.
Abstract:
Ibrutinib, a Bruton's tyrosine kinase inhibitor, has been increasingly widely used in relapsed and refractory mantle cell lymphoma (MCL) and chronic lymphocytic leukaemia [1, 2]. With its use becoming more common, there have been emerging case reports of opportunistic infections like cryptococcal infections [3-8]. These infections in patients receiving ibrutinib were mostly reported in patients with chronic lymphocytic leukaemia, who have poor immune reconstitution. Here, we report two cases of cryptococcal meningoencephalitis in patients with MCL on ibrutinib.
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