β-Arylation of oxime ethers using diaryliodonium salts through activation of inert C(sp)-H bonds using a palladium
Jing Peng1, Chao Chen1, Chanjuan Xi1
1Key Laboratory of Bioorganic Phosphorus Chemistry & Chemical Biology (Ministry of Education) , Department of Chemistry , Tsinghua University , Beijing 100084 , China .
Abstract:
An efficient method of selective β-arylation of oxime ethers was realized by using a palladium catalyst with diaryliodonium salts as the key arylation reagents. The reaction proceeded smoothly through the activation of inert C(sp3)-H bonds to give corresponding ketones and aldehydes. This convenient procedure can be successfully applied to construct new C(sp3)-C(sp2) bonds on a number of complex molecules derived from natural products and thus serves as a practical synthetic tool for direct late-stage C(sp3)-H functionalization.
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