Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

6.0K
Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H01:13

meta-Directing Deactivators: –NO2, –CN, –CHO, –⁠CO2R, –COR, –CO2H

6.7K
All meta-directing substituents are deactivating groups. These substituents withdraw electrons from the aromatic ring, making the ring less reactive toward electrophilic substitution. For example, the nitration of nitrobenzene is 100,000 times slower than that of benzene because of the deactivating effect of the nitro group. The first step in an electrophilic aromatic substitution is the addition of an electrophile to form a resonance-stabilized carbocation. The energy diagrams for...
6.7K
Cleavage and Blastulation01:33

Cleavage and Blastulation

50.3K
After a large-single-celled zygote is produced via fertilization, the process of cleavage occurs while zygotes travel through the uterine tube. Cleavage is a mitotic cell division that does not result in growth. With each round of successive cell division, daughter cells get increasingly smaller.
50.3K
Reproductive Cloning01:27

Reproductive Cloning

32.8K
Reproductive cloning is the process of producing a genetically identical copy—a clone—of an entire organism. While clones can be produced by splitting an early embryo—similar to what happens naturally with identical twins—cloning of adult animals is usually done by a process called somatic cell nuclear transfer (SCNT).
Somatic Cell Nuclear Transfer
In SCNT, an egg cell is taken from an animal and its nucleus is removed, creating an enucleated egg. Then a somatic...
32.8K
Bacterial Signaling01:30

Bacterial Signaling

40.9K
Bacterial signaling can occur within bacteria (intracellular) or between bacteria (intercellular). At times, a group of bacteria behaves like a community. To achieve this, they engage in quorum sensing, the perception of higher cell density that causes changes in gene expression. Quorum sensing involves both extracellular and intracellular signaling. The signaling cascade starts with a molecule called an autoinducer (AI). Individual bacteria produce AIs that move out of the bacterial cell...
40.9K
In-vitro Mutagenesis01:16

In-vitro Mutagenesis

16.4K
To learn more about the function of a gene, researchers can observe what happens when the gene is inactivated or “knocked out,” by creating genetically engineered knockout animals. Knockout mice have been particularly useful as models for human diseases such as cancer, Parkinson’s disease, and diabetes.
16.4K

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Three-Dimensional Bioprinting of Regenerative Cartilage Constructs with Directional Ionically Derived Stiffness Gradients.

Journal of functional biomaterials·2025
Same author

Harnessing plasticity in sequential metamaterials for ideal shock absorption.

Nature·2024
Same author

Elasticity and rheology of auxetic granular metamaterials.

Proceedings of the National Academy of Sciences of the United States of America·2024
Same author

Diffusive kinks turn kirigami into machines.

Nature communications·2024
Same author

Orthopedic meta-implants.

APL bioengineering·2024
Same author

4D printed shape-shifting biomaterials for tissue engineering and regenerative medicine applications.

Biofabrication·2024
Same journal

Melanocortin 1 receptor-targeted peptide-functionalized liposomes for enhanced melanocyte-preferential drug delivery and anti-melanogenic efficacy.

Journal of materials chemistry. B·2026
Same journal

Recent progress in side-chain amino acid-based polymers: synthesis, self-assembly, and emerging biomedical applications.

Journal of materials chemistry. B·2026
Same journal

Bioinspired electrospun nanofibrous dressings loaded with Mentha-derived exosome-like vesicles for antibacterial and immunomodulatory burn healing.

Journal of materials chemistry. B·2026
Same journal

On demand functionality of an NIR-enhanced nanozyme catalyst for infected wound healing.

Journal of materials chemistry. B·2026
Same journal

Positively charged, phenolic hydroxyl and anthraquinone structured polystyrene microspheres targeting dual elimination of bacterial pathogens and pathogen-associated molecular patterns for sepsis therapy.

Journal of materials chemistry. B·2026
Same journal

Carbon dot-decorated Ni-MOF heterojunction sonozymes for enhanced sonodynamic-chemodynamic cancer therapy.

Journal of materials chemistry. B·2026
See all related articles

Related Experiment Video

Updated: Feb 8, 2026

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
06:39

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease

Published on: February 18, 2020

7.2K

Towards deployable meta-implants.

F S L Bobbert1, S Janbaz1, A A Zadpoor1

  • 1Department of Biomechanical Engineering , Delft University of Technology , Mekelweg 2 , Delft 2628CD , The Netherlands . Email: f.s.l.bobbert@tudelft.nl ; Tel: +31-15-2786780.

Journal of Materials Chemistry. B
|June 19, 2018
PubMed
Summary
This summary is machine-generated.

Researchers developed novel deployable meta-implants using bi-stable elements for minimally invasive orthopedic surgery. These meta-implants offer unique properties for superior performance and customizable deployment.

More Related Videos

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model
05:52

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model

Published on: November 4, 2021

3.4K
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K

Related Experiment Videos

Last Updated: Feb 8, 2026

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease
06:39

Novel Percutaneous Approach for Deployment of 3D Printed Coronary Stenosis Implants in Swine Models of Ischemic Heart Disease

Published on: February 18, 2020

7.2K
Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model
05:52

Myocardial Infarction by Percutaneous Embolization Coil Deployment in a Swine Model

Published on: November 4, 2021

3.4K
Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia
04:34

Meta-Analysis of the Effectiveness and Safety of Shugan Jieyu Capsules for the Treatment of Insomnia

Published on: February 17, 2023

1.6K

Area of Science:

  • Biomaterials Science
  • Mechanical Engineering
  • Orthopedic Surgery

Background:

  • Meta-biomaterials possess unique properties not found in nature.
  • These properties offer potential for advanced orthopedic implants (meta-implants).
  • Current orthopedic implants can be invasive and lack adaptability.

Purpose of the Study:

  • To design and develop deployable meta-implants using bi-stable elements.
  • To explore the potential of meta-implants for minimally invasive orthopedic applications.
  • To investigate the influence of design parameters on meta-implant performance.

Main Methods:

  • Utilized bi-stable elements based on snap-through instability.
  • Designed five types of meta-implants: radially-deployable, auxetic, and axially-deployable structures.
  • Analyzed the impact of geometrical parameters and arrangement of bi-stable elements.

Main Results:

  • Successfully designed deployable meta-implants with compact retracted and load-bearing deployed states.
  • Demonstrated that meta-implant properties (multi-stability, deployment force, stiffness) are tunable.
  • Showcased dependence of performance on geometric parameters and arrangement of bi-stable elements.

Conclusions:

  • Deployable meta-implants offer a promising approach for minimally invasive orthopedic surgery.
  • Bi-stable elements provide a mechanism for creating adaptable and high-performance meta-implants.
  • Further research into geometric optimization can enhance meta-implant functionality for various orthopedic needs.