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Updated: Feb 8, 2026

Ex Vivo Preparations of the Intact Vomeronasal Organ and Accessory Olfactory Bulb
Published on: August 4, 2014
Amygdala Corticofugal Input Shapes Mitral Cell Responses in the Accessory Olfactory Bulb
Livio Oboti1, Eleonora Russo2, Tuyen Tran1
1Center for Neuroscience Research, Children's National Health System, Washington, DC 20010.
Abstract:
Interconnections between the olfactory bulb and the amygdala are a major pathway for triggering strong behavioral responses to a variety of odorants. However, while this broad mapping has been established, the patterns of amygdala feedback connectivity and the influence on olfactory circuitry remain unknown. Here, using a combination of neuronal tracing approaches, we dissect the connectivity of a cortical amygdala [posteromedial cortical nucleus (PmCo)] feedback circuit innervating the mouse accessory olfactory bulb. Optogenetic activation of PmCo feedback mainly results in feedforward mitral cell (MC) inhibition through direct excitation of GABAergic granule cells. In addition, LED-driven activity of corticofugal afferents increases the gain of MC responses to olfactory nerve stimulation. Thus, through corticofugal pathways, the PmCo likely regulates primary olfactory and social odor processing.
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