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Related Concept Videos

Overview of the Cardiovascular System01:14

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The cardiovascular system is a vital transportation system in the body. It comprises the heart and blood vessels and facilitates the exchange of gases, nutrients, and waste products.
Heart
The heart is the central pump of the cardiovascular system that circulates blood throughout the body. It comprises two atria receiving the blood and two ventricles pumping blood out of the heart. Their rhythmic contractions, called heartbeats, ensure that blood flow remains continuous.
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Lipids include a diverse group of compounds that are largely nonpolar in nature. This is because they are hydrocarbons that include mostly nonpolar carbon-carbon or carbon-hydrogen bonds. Non-polar molecules are hydrophobic (“water fearing”), or insoluble in water. Lipids perform many different functions in a cell. Cells store energy for long-term use in the form of fats. Lipids also provide insulation from the environment for plants and animals. For example, they help keep aquatic...
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In 1865, August Kekule suggested the structure of benzene according to the structural theory of organic chemistry based on the three assertions—formula of benzene is C6H6, all the hydrogens of benzene are equivalent, and each carbon must have four bonds due to its tetravalency.
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In Silico Clinical Trials for Cardiovascular Disease
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Structural modelling of the cardiovascular system.

Benjamin Owen1, Nicholas Bojdo2, Andrey Jivkov2

  • 1School of Mechanical, Aerospace and Civil Engineering, University of Manchester, George Begg Building, Manchester, M1 3BB, UK. benjamin.owen@manchester.ac.uk.

Biomechanics and Modeling in Mechanobiology
|June 19, 2018
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Summary
This summary is machine-generated.

This review summarizes advances in computational cardiovascular structural modeling. It covers numerical methods, constitutive models for hyperelastic materials, and procedures for simulating cardiovascular structures and diseases.

Keywords:
Cardiovascular structureContinuumDiscreteModelling

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Area of Science:

  • Biomedical Engineering
  • Computational Mechanics
  • Cardiovascular Physiology

Background:

  • Cardiovascular computational modelling is an interdisciplinary challenge.
  • Requires expertise in physiology, material mechanics, fluid dynamics, and biochemistry.
  • Advances in numerical methods and constitutive models are crucial for accurate simulations.

Purpose of the Study:

  • To summarize recent advances in cardiovascular structural modeling.
  • To provide an accessible reference for newcomers to the field.
  • To link physiological components and pathologies to constitutive modeling developments.

Main Methods:

  • Overview of hyperelastic material models (classical and phenomenological).
  • Analysis of numerical methods and modeling procedures.
  • Integration of clinical and engineering approaches.

Main Results:

  • Cardiovascular structural modeling incorporates diverse disciplines.
  • Hyperelastic models form the basis for material deformation.
  • Models are increasingly applied across various scales and applications.
  • High-performance computing influences modeling choices.

Conclusions:

  • Computational modeling of the cardiovascular system is rapidly advancing.
  • Interdisciplinary collaboration is key to progress.
  • The trend shows wider applicability of models and impact of computing resources.