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Beyond the evoked/intrinsic neural process dichotomy.

Taylor Bolt1, Michael L Anderson2,3, Lucina Q Uddin1,4

  • 1Department of Psychology, University of Miami, Coral Gables, FL, USA.

Network Neuroscience (Cambridge, Mass.)
|June 19, 2018
PubMed
Summary

The dichotomy between intrinsic and task-evoked brain activity is artificial. Brain function arises from dynamic constraints, not separate components, requiring a reconceptualization of neuroimaging analysis.

Keywords:
Enabling constraintIntrinsic activityNeural variabilitySynergyTask-evoked activity

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Functional Neuroimaging

Background:

  • Contemporary functional neuroimaging often contrasts intrinsic brain activity with task-evoked activity.
  • This evoked/intrinsic dichotomy has traditionally framed cognitive neuroscience research.
  • The separation of intrinsic and task-evoked activity may not accurately represent brain function.

Purpose of the Study:

  • To challenge the artificial dichotomy between intrinsic and task-evoked brain activity.
  • To propose an alternative framework for understanding brain function based on empirical data.
  • To advocate for a reconceptualization of functional brain activity analysis.

Main Methods:

  • Review of empirical data on intrinsic and task-evoked brain activity.
  • Theoretical argumentation against the separation of intrinsic and task-evoked components.
  • Introduction of the 'enabling constraint' framework.

Main Results:

  • Empirical data demonstrate a functional interdependence between intrinsic and task-evoked activity.
  • The brain's spatiotemporal dynamics are not separable into intrinsic and task-evoked components.
  • Brain function is characterized by mutual constraints enabling task-appropriate configurations.

Conclusions:

  • The evoked/intrinsic dichotomy is an artificial construct.
  • Brain function should be viewed as a dynamic system of enabling constraints.
  • Future research should adopt this integrated perspective, moving beyond separable components.