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  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Motivational Valence Is Determined By Striatal Melanocortin 4 Receptors.
  1. Home
  3. Research Domains
  5. Biomedical And Clinical Sciences
  7. Oncology And Carcinogenesis
  9. Predictive And Prognostic Markers
  11. Motivational Valence Is Determined By Striatal Melanocortin 4 Receptors.

Related Experiment Video

Rodent Brain Microinjection to Study Molecular Substrates of Motivated Behavior
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Motivational valence is determined by striatal melanocortin 4 receptors.

Anna Mathia Klawonn1, Michael Fritz1, Anna Nilsson1

  • 1Department of Clinical and Experimental Medicine, Linköping University, Linköping, Sweden.

The Journal of Clinical Investigation
|June 19, 2018

View abstract on PubMed

Summary
This summary is machine-generated.

Melanocortin 4 receptors (MC4Rs) are crucial for negative valence assignment. Lacking MC4Rs flips aversion to reward, highlighting their role in processing harmful stimuli.

Keywords:
InflammationMelanocortinNeuroscience

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Area of Science:

  • Neuroscience
  • Behavioral Science
  • Molecular Biology

Background:

  • Assigning valence to stimuli is critical for survival.
  • Aversive signaling underlies suffering in chronic diseases like cancer and depression.
  • Melanocortin 4 receptors (MC4Rs) are implicated in various physiological processes.

Purpose of the Study:

  • To investigate the role of MC4Rs in aversive processing.
  • To understand how MC4Rs mediate the negative motivational valence of harmful stimuli.

Main Methods:

  • Utilized genetically modified mice lacking MC4Rs.
  • Employed a behavioral avoidance test to assess aversion.
  • Examined dopamine system activity and MC4R reexpression effects.

Main Results:

  • Mice lacking MC4Rs showed preference or indifference to aversive stimuli, unlike normal mice.
  • This aversion-to-reward flip was dopamine-dependent, with altered dopamine system activity.
  • Reexpressing MC4Rs in specific brain regions normalized aversion responses.

Conclusions:

  • Striatal MC4Rs are essential for assigning negative motivational valence to harmful stimuli.
  • Melanocortin signaling via MC4Rs plays a critical role in aversive processing.
  • These findings offer insights into the neurobiological basis of suffering and disease.