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Updated: Feb 8, 2026

Amplifying and Quantifying HIV-1 RNA in HIV Infected Individuals with Viral Loads Below the Limit of Detection by Standard Clinical Assays
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Clinical research cerebral MRI findings in HIV-positive subjects and appropriate controls

Srishti Chhabra1, Jonathan Underwood1,2, James H Cole3

  • 1Section of Infectious Diseases, Department of Medicine, Imperial College London.

AIDS (London, England)
|June 19, 2018
PubMed

Insights

Cerebral MRI abnormalities are common in people with HIV (PLWH), but this study found no differences compared to controls. Abnormalities were linked to age and hypertension, not HIV status.

Area of Science:

  • Neuroimaging
  • Infectious Diseases
  • Neurology

Background:

  • Cerebral magnetic resonance imaging (MRI) abnormalities are frequently observed in people living with HIV (PLWH).
  • This study aimed to compare clinical cerebral MRI findings between PLWH and a lifestyle-matched control group.
  • The study included 59 PLWH and 29 controls.

Discussion:

  • Despite a high prevalence of abnormalities (47.7%) in PLWH, including white-matter lesions, microvascular disease, and cerebral volume loss, no significant differences were found when compared to controls.
  • These findings suggest that factors other than HIV serostatus are primarily associated with cerebral MRI abnormalities.
  • Age and hypertension emerged as significant correlates of these abnormalities.

Key Insights:

  • Cerebral MRI abnormalities are prevalent in PLWH but not uniquely associated with HIV.
  • Age and hypertension are key determinants of cerebral MRI abnormalities, irrespective of HIV status.
  • The study highlights the importance of considering comorbidities and aging in the neurological health of PLWH.

Outlook:

  • Further research should investigate the specific mechanisms linking age and hypertension to cerebral MRI changes in PLWH.
  • Longitudinal studies could elucidate the progression of these abnormalities over time.
  • Clinical management strategies for PLWH should consider the impact of aging and common comorbidities on brain health.

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