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Updated: Feb 8, 2026

Determining Pain Detection and Tolerance Thresholds Using an Integrated, Multi-Modal Pain Task Battery
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Ibuprofen for Pain Control in Children: New Value for an Old Molecule

Dimitri Poddighe, Ilaria Brambilla, Amelia Licari

    Pediatric Emergency Care
    |June 19, 2018
    PubMed

    Insights

    Ibuprofen is an effective pain reliever for children, showing better results than acetaminophen for musculoskeletal pain and comparable efficacy to acetaminophen-codeine. It offers a good safety profile for managing various acute pain conditions in pediatric patients.

    Area of Science:

    • Pediatric pharmacology
    • Pain management
    • Evidence-based medicine

    Background:

    • Acute pain is a frequent pediatric complaint in healthcare settings.
    • Regulatory agencies have issued warnings concerning opioid use, including codeine, in children.
    • This highlights the need for alternative analgesics in pediatric care.

    Purpose of the Study:

    • To review the pharmacology of ibuprofen for pediatric pain.
    • To evaluate current evidence on ibuprofen's efficacy in various clinical scenarios.
    • To compare ibuprofen with acetaminophen and codeine in children.

    Main Methods:

    • Systematic literature search of PubMed and MEDLINE (1985-2017).
    • Inclusion of studies on ibuprofen for acute pediatric pain management.
    • Analysis of safety, efficacy, and comparative data with other analgesics.

    Main Results:

    • Ibuprofen is more effective than acetaminophen for musculoskeletal pain in children.
    • Ibuprofen shows comparable efficacy to acetaminophen-codeine for certain pain types.
    • Effective for toothache, oral/pharyngeal inflammation, headaches, and postoperative pain, including after tonsillectomy.

    Conclusions:

    • Ibuprofen is the most extensively studied nonsteroidal anti-inflammatory drug for pediatric acute pain.
    • It demonstrates a favorable safety profile and proven effectiveness across different pediatric pain conditions.
    • Its utility varies by clinical context, underscoring the importance of specific application.
    Abstract

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