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Dermatologic Manifestations of Colchicine Intoxication
Asuman Gürkan1, Melahat Melek Oğuz2, Esin Boduroğlu Cengiz3
1From the Departments of Dermatology.
Pediatric Emergency Care
|June 19, 2018
Summary
Colchicine poisoning presents in three phases, with a rare maculopapular/purpuric rash appearing in the second phase. This case highlights unusual dermatologic manifestations alongside typical alopecia in colchicine toxicity.
Area of Science:
- Pharmacology
- Toxicology
- Dermatology
Background:
- Colchicine, an anti-inflammatory agent, has a narrow therapeutic index, making toxicity a concern.
- Colchicine poisoning classically manifests in three distinct phases with systemic and organ-specific symptoms.
Observation:
- This report details a case of colchicine intoxication in a 16-year-old female.
- The patient presented with a maculopapular/purpuric rash and subsequent alopecia.
Findings:
- Dermatologic manifestations, including maculopapular/purpuric eruptions, can occur during the second phase of colchicine toxicity, preceding multiorgan failure.
- Alopecia is a recognized feature of the third phase, indicating organ derangement resolution.
Implications:
- This case expands the understanding of colchicine's dermatologic toxic effects.
- Recognizing these specific skin eruptions may aid in earlier diagnosis and management of colchicine poisoning.
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