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Circadian Entrainment of Drosophila Melanogaster
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CircadiOmics: circadian omic web portal.
Nicholas Ceglia1,2, Yu Liu1,2, Siwei Chen1,2
1Department of Computer Science, University of California, Irvine, CA 92617, USA.
Nucleic Acids Research
|June 19, 2018
Summary
CircadiOmics now offers a comprehensive web server for circadian omic data, integrating over 227 datasets. This resource enables visualization and analysis of biological oscillations across various conditions and species.
Area of Science:
- Chronobiology
- Genomics
- Systems Biology
Background:
- Circadian rhythms are crucial biological processes impacting all life.
- Understanding circadian mechanisms requires integrated analysis of large omic datasets.
- Existing resources lack a comprehensive platform for circadian omic data access and mining.
Purpose of the Study:
- To introduce the updated CircadiOmics web server, a centralized resource for circadian omic data.
- To provide a powerful platform for visualizing and analyzing circadian oscillations.
- To facilitate the download of publication-ready periodicity statistics.
Main Methods:
- The CircadiOmics web server integrates 227 high-throughput omic datasets.
- Data includes over 74 million measurements sampled over 24-hour cycles.
- Periodicity statistics are calculated using BIO_CYCLE and other methods.
Main Results:
- CircadiOmics provides a comprehensive repository of circadian omic data.
- Users can visualize and compare oscillatory trajectories across species, tissues, and conditions.
- Publication-ready figures and tables of periodicity statistics are available for download.
Conclusions:
- The updated CircadiOmics serves as a powerful web portal for integrated circadian omic data analysis.
- It addresses the need for a comprehensive resource for studying circadian rhythms.
- Enhanced features and performance support advanced research in chronobiology.
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