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Related Experiment Video

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Rapid Isolation of Human Breast Milk-Derived Extracellular Vesicles
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Quetiapine Excretion Into Human Breast Milk.

Parvaneh Yazdani-Brojeni, Reo Tanoshima, Nobuko Taguchi

  • 1Department of Computer Science, University of Toronto.

Journal of Clinical Psychopharmacology
|June 19, 2018
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Summary
This summary is machine-generated.

Quetiapine use during breastfeeding results in very small infant exposure levels via breast milk, according to pharmacokinetic data. This study provides crucial information for assessing quetiapine safety in nursing mothers.

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Area of Science:

  • Pharmacology
  • Neonatal Medicine
  • Maternal Health

Background:

  • Assessing quetiapine safety during breastfeeding is difficult due to limited data.
  • Understanding drug transfer into breast milk is vital for infant well-being.

Purpose of the Study:

  • To quantify quetiapine concentrations in breast milk.
  • To estimate infant exposure levels to quetiapine transferred via breast milk.

Main Methods:

  • A pharmacokinetic study involving lactating women using quetiapine.
  • Analysis of quetiapine in milk and plasma using liquid chromatography-tandem mass spectrometry.
  • Determination of milk/plasma drug concentration ratios and infant dose estimations.

Main Results:

  • Nine women on fast-release quetiapine (mean dose 41 mg/d) were analyzed.
  • Mean milk concentration was 5.7 ng/mL, with a mean milk/plasma ratio of 0.47.
  • Estimated infant quetiapine dose was 0.16% of the weight-adjusted maternal dose.

Conclusions:

  • Infant exposure to quetiapine through breast milk is predicted to be minimal.
  • Findings suggest a potentially favorable safety profile for quetiapine use in breastfeeding mothers.
  • Further research may be warranted to confirm long-term infant outcomes.