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A sialoadenectomy is associated with an increased risk of coronary heart disease: A three-year follow-up study

Shih-Han Hung1,2, Chin-Hui Su3, Herng-Ching Lin4

  • 1Department of Otolaryngology, Taipei Medical University Hospital, Taipei, Taiwan.

Plos One
|June 19, 2018
PubMed

Insights

Surgical removal of salivary glands (sialoadenectomy) may increase the risk of developing coronary heart disease (CHD). This study found a 2.43 times higher hazard ratio for CHD in patients who underwent sialoadenectomy.

Area of Science:

  • Cardiology
  • Surgical Oncology
  • Epidemiology

Background:

  • Long-term adverse effects of sialoadenectomy are not well-documented.
  • Sialoadenectomy involves the surgical removal of salivary glands.
  • Understanding post-surgical risks is crucial for patient care.

Purpose of the Study:

  • To investigate the association between sialoadenectomy and the risk of coronary heart disease (CHD).
  • To estimate the long-term risk of CHD following sialoadenectomy.

Main Methods:

  • Retrospective cohort study using Taiwan's Longitudinal Health Insurance Database 2005.
  • Included 608 patients who underwent sialoadenectomy and 1824 propensity score-matched controls.
  • Followed patients for 3 years to identify CHD diagnoses.

Main Results:

  • Incidence rates of CHD were 3.87 per 100 person-years for sialoadenectomy patients vs. 1.79 for controls.
  • Sialoadenectomy was associated with a hazard ratio of 2.43 for CHD.
  • A statistically significant association was observed between sialoadenectomy and increased CHD risk.

Conclusions:

  • Sialoadenectomy is associated with an increased risk of developing coronary heart disease.
  • Further research is needed to elucidate the mechanisms behind this association.
  • This finding highlights potential long-term cardiovascular implications of sialoadenectomy.

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