Jove
Visualize
Contact Us
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Concept Videos

Self-Efficacy01:29

Self-Efficacy

233
Self-efficacy is the belief in one's capacity to organize and execute actions necessary to manage prospective situations. This belief significantly influences how individuals approach goals, tasks, and challenges across different domains of life.Psychological and Educational ImpactsIndividuals with strong self-efficacy are more resilient in the face of difficulties. They are more likely to adopt effective problem-solving strategies, persist through obstacles, and regulate emotions such as...
233
Gene Therapy00:59

Gene Therapy

27.7K
Gene therapy is a technique where a gene is inserted into a person’s cells to prevent or treat a serious disease. The added gene may be a healthy version of the gene that is mutated in the patient, or it could be a different gene that inactivates or compensates for the patient’s disease-causing gene. For example, in patients with severe combined immunodeficiency (SCID) due to a mutation in the gene for the enzyme adenosine deaminase, a functioning version of the gene can be...
27.7K
Group Therapy01:26

Group Therapy

451
Group therapy is a sociocultural approach to psychological treatment, where individuals with shared psychological challenges come together under the guidance of a mental health professional. This therapeutic modality offers unique opportunities for individuals to connect, share, and grow within the context of a supportive group. By fostering mutual understanding and collaboration, group therapy can address a range of psychological concerns effectively, often complementing or surpassing the...
451
Cancer Therapies02:49

Cancer Therapies

10.2K
Cancer therapies are various modes of treatment, such as surgery, radiation therapy, and chemotherapy that are administered to cancer patients.
However, cancer treatments can pose several challenges, as therapies used to kill cancer cells are generally also toxic to normal cells. Moreover, cancer cells mutate rapidly and can develop resistance to chemical agents or radiation therapy. Besides, all types of cancer cells may not respond to the same therapy. Some cancer cells respond to one...
10.2K
Behavior Therapy01:22

Behavior Therapy

729
Behavior therapy incorporates diverse techniques rooted in classical conditioning principles to address maladaptive behaviors and anxiety disorders. These methods aim to reduce avoidance behaviors, foster adaptive coping mechanisms, and alter associations between stimuli and responses, making them effective in a wide range of therapeutic contexts.
Exposure therapy is a cornerstone of behavioral treatment for anxiety disorders. It involves systematic exposure to feared stimuli, either in real...
729
Drug Therapy01:28

Drug Therapy

302
The advent of drug therapy has profoundly shaped modern mental health care, providing targeted treatments for a range of psychological disorders. Psychotherapeutic drugs, classified into antianxiety, antidepressant, and antipsychotic medications, address symptoms across anxiety disorders, mood disorders, and schizophrenia. While these medications have transformed patient outcomes, they require careful management due to their potential side effects and limitations.
Antianxiety Medications
302

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

Lactate Dehydrogenase-5 and Tumor-Infiltrating Lymphocytes in Prostate Cancer Patients Undergoing Radical Hypofractionated Radiotherapy.

Cancers·2026
Same author

HBV pgRNA induces chronic inflammation in an IL-1β-dependent manner.

Frontiers in immunology·2026
Same author

Life-Threatening Gastrointestinal Bleeding Revealing a Rare Coexistence of Ampullary Ganglioneuroma and Pancreatic Neuroendocrine Tumor: A Case Report.

Diagnostics (Basel, Switzerland)·2026
Same author

Metabolism and Immunity-Adapted Radiotherapy (M.I.A.R): A Conceptual Framework for Overcoming the Therapeutic Plateau in Clinical Radiotherapy.

Current oncology (Toronto, Ont.)·2026
Same author

Pseudoprogression of a head and neck cutaneous squamous cell carcinoma treated with anti-PD-1 immunotherapy: a case report and review of the literature.

Chemotherapy·2026
Same author

MRI-Derived Biomarkers and Radiomic Signatures for Early, Dose-Dependent Evaluation of Prostate Cancer Radiotherapy: An Exploratory Study.

Journal of imaging·2026

Related Experiment Video

Updated: Feb 8, 2026

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
06:18

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue

Published on: June 21, 2018

12.1K

Warburg effect, lactate dehydrogenase, and radio/chemo-therapy efficacy.

Michael I Koukourakis1, Alexandra Giatromanolaki2

  • 1a Department of Radiotherapy and Oncology, Medical School, Democritus University of Thrace , Alexandroupolis , Greece.

International Journal of Radiation Biology
|June 19, 2018
PubMed
Summary

Lactate dehydrogenase 5 (LDH5) plays a key role in cancer cell metabolism, shifting cells to anaerobic pathways. Targeting LDH5 offers a promising strategy for cancer treatment and improving radiotherapy response.

Keywords:
CancerLDH5LDHAanaerobic metabolismglycolysisprognosisradiotherapy

More Related Videos

Author Spotlight: Treating Frozen Shoulder with Small Needle Knife Therapy
05:52

Author Spotlight: Treating Frozen Shoulder with Small Needle Knife Therapy

Published on: November 17, 2023

2.3K
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.2K

Related Experiment Videos

Last Updated: Feb 8, 2026

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue
06:18

Mapping Metabolism: Monitoring Lactate Dehydrogenase Activity Directly in Tissue

Published on: June 21, 2018

12.1K
Author Spotlight: Treating Frozen Shoulder with Small Needle Knife Therapy
05:52

Author Spotlight: Treating Frozen Shoulder with Small Needle Knife Therapy

Published on: November 17, 2023

2.3K
Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro
08:04

Cytotoxic Efficacy of Photodynamic Therapy in Osteosarcoma Cells In Vitro

Published on: March 18, 2014

13.2K

Area of Science:

  • Biochemistry
  • Oncology
  • Molecular Biology

Background:

  • Cancer cells exhibit anaerobic glucose metabolism (Warburg effect), even in oxygen-rich environments.
  • Hypoxia and related gene responses drive cancer cells towards anaerobic metabolic pathways.
  • Lactate dehydrogenase 5 (LDH5) is a critical enzyme in pyruvate-to-lactate conversion.

Purpose of the Study:

  • To review the significance of lactate dehydrogenase 5 (LDH5) in cancer.
  • To explore LDH5's role as a prognostic marker and predictor of treatment response.
  • To discuss LDH5 as a therapeutic target for cancer treatment and radiosensitization.

Main Methods:

  • Review of clinical, translational, and experimental data.
  • Focus on the LDHA gene and its product, the LDH5 isoenzyme.
  • Analysis of LDH5's involvement in cancer cell metabolism and response to therapy.

Main Results:

  • LDH5 is implicated in the shift to anaerobic metabolism in cancer cells.
  • LDH5 serves as a prognostic indicator for cancer patients.
  • LDH5 predicts response to radiotherapy and chemotherapy.
  • LDH5 is a potential target for cancer therapy and radiosensitization.

Conclusions:

  • The LDHA gene and LDH5 isoenzyme are uniquely important in cancer.
  • Targeting LDH5 presents a novel strategy for metabolic cancer treatment.
  • Further research into LDH5 could lead to improved cancer therapies and radiosensitization.