Philadelphia chromosome-positive lymphoblastic lymphoma-Is it rare or underdiagnosed?
Ahmad Alshomar1, Riad El Fakih2
1Medicine Department, College of Medicine, Qassim University, Saudi Arabia; Adult Hematology, Bone Marrow Transplantation, Oncology Center, King Faisal Specialist Hospital and Research Center, Riyadh, Saudi Arabia.
Abstract:
Lymphoblastic lymphomas (LBLs) are neoplasms of precursor B and T cells; they are considered in the same spectrum as precursor B and T cell acute lymphoblastic leukemia (ALL). The World Health Organization classification classifies both LBL and ALL as one disease entity. While chromosome abnormalities are well defined with all of their therapeutic and prognostic implications in ALL, these are not well studied in LBL. Here, we describe a case of Philadelphia chromosome-positive LBL and review the available literature regarding this entity.
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