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Quantifying Synapses: an Immunocytochemistry-based Assay to Quantify Synapse Number
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Multisynaptic cooperation shapes single glutamatergic synapse response.

Vito Di Maio1, Silvia Santillo1, Francesco Ventriglia1

  • 1Istituto di Scienze Applicate e Sistemi Intelligenti (ISASI) del CNR, Italy.

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|June 19, 2018
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Summary
This summary is machine-generated.

Excitatory activity in dendrites influences single synapse output, affecting synaptic strength and plasticity. This occurs even below spike threshold, impacting phenomena like short-term and long-term potentiation.

Keywords:
AMPADendritic activityGlutamatergic synapseLTPNMDASTPSynaptic model

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Area of Science:

  • Neuroscience
  • Computational Neuroscience
  • Synaptic Plasticity

Background:

  • Neuronal dendrites integrate numerous excitatory inputs.
  • Synaptic activity influences neuronal excitability and plasticity.
  • The impact of background dendritic activity on single synapse function is not fully understood.

Purpose of the Study:

  • To investigate how background excitatory synaptic activity in dendrites affects the output of a single glutamatergic synapse.
  • To model the influence of varying numbers of active synapses on single synaptic parameters.

Main Methods:

  • Simulated synaptic diffusion and excitatory postsynaptic potential (EPSP) generation.
  • Varied the number of active synapses in a computational model.

Main Results:

  • Increased dendritic activity modulated single synapse output parameters, including amplitude and time course.
  • Subthreshold dendritic activity influenced NMDA-receptor component activation.
  • These changes consequently affected short-term plasticity (STP) and long-term potentiation (LTP).

Conclusions:

  • Dendritic integration of excitatory inputs significantly impacts individual synapse function, even without somatic spike generation.
  • Background synaptic activity plays a crucial role in regulating synaptic plasticity mechanisms like STP and LTP.