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Updated: Feb 8, 2026

High Frequency Ultrasound for the Analysis of Fetal and Placental Development In Vivo
Published on: November 8, 2018
Hyperemesis gravidarum-Is it a cause of abnormal fetal brain development?
Gideon Koren1, Asher Ornoy2, Matitiahu Berkovitch3
1Motherisk Israel, Clinical Pharmacology and Toxicology Unit, Assaf Harofeh Medical Center, Zerifin; Maccabi Institute for Research and Innovation, Israel; Sackler Faculty of Medicine, Tel Aviv University, Israel; Westen University, ON, Canada; The Hebrew University, Israel.
Abstract:
Hyperemesis gravidarum (HG) is characterized by severe gestational nausea and vomiting, leading to dehydration, electrolyte imbalance and nutritional deficits. HG adversely affects the health and wellbeing of the woman. However, the detrimental impact of HG on fetal brain development has not been addressed. We evaluate herein the emerging evidence suggesting that HG interferes with human brain development, and discuss putative mechanisms. Evidence emerges from prospective developmental studies in offspring exposed in utero to HG, from studies of pregnancy outcome after in utero exposure to famine, as well as evidence on specific nutritional deficiencies affecting fetal brain development.
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