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Measuring Single-Cell Aging with an Imaging-based Biomarker of Chromatin and Epigenetic Aging
Published on: January 30, 2026
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Nrf2: Molecular and epigenetic regulation during aging
A Silva-Palacios1, M Ostolga-Chavarría2, C Zazueta2
1Departamento de Ciencias de la Salud, DCBS, Universidad Autónoma Metropolitana-Iztapalapa, Ciudad de Mexico, 09340, Mexico; Departamento de Biomedicina Cardiovascular, Instituto Nacional de Cardiología-Ignacio Chávez, Ciudad de Mexico, Mexico; Posgrado en Biología Experimental, UAM-I, Mexico.
Ageing Research Reviews
|June 19, 2018
Summary
Aging is linked to declining cellular protection. This review explores how regulators like Keap1 and GSK-3β impact the antioxidant Nrf2 pathway, crucial for healthy aging and preventing age-related diseases.
Area of Science:
- Cellular and Molecular Biology
- Aging Research
- Biochemistry
Background:
- Increased lifespan is associated with age-related diseases and loss of cellular integrity.
- Nuclear factor-erythroid 2-p45 derived factor 2 (Nrf2) regulates antioxidant and cytoprotective genes.
- Nrf2 activation is a potential strategy for promoting healthy aging.
Purpose of the Study:
- To review evidence on the regulation of Nrf2 activity during aging.
- To identify key regulatory factors impacting Nrf2 function in the elderly.
- To understand mechanisms that maintain cellular protection during aging.
Main Methods:
- Literature review of experimental approaches and findings.
- Compilation of evidence on Nrf2 regulators in aging models.
- Analysis of the impact of specific proteins and miRNAs on Nrf2 activity.
Main Results:
- Negative regulators of Nrf2, including Keap1, GSK-3β, Bach1, p53, Hrd1, and miRNAs, may affect Nrf2 activity in elderly individuals.
- Changes in the levels or activity of these regulators are implicated in the decreased Nrf2 activity observed in aging models.
- Disruption of Nrf2 regulation might contribute to the loss of cellular protection during aging.
Conclusions:
- Understanding the regulatory network of Nrf2 is critical for developing strategies to combat aging.
- Targeting Nrf2 regulatory mechanisms can potentially prevent the decline in cellular protective responses.
- This knowledge is essential for promoting healthy aging and mitigating age-related diseases.
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