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ATP is a highly unstable molecule. Unless quickly used to perform work, ATP spontaneously dissociates into ADP and inorganic phosphate (Pi), and the free energy released during this process is lost as heat. The energy released by ATP hydrolysis is used to perform work inside the cell and depends on a strategy called energy coupling. Cells couple the exergonic reaction of ATP hydrolysis with endergonic reactions, allowing them to proceed.
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A multifunctional multimaterial system for on-demand protein release.

Deniz Ceylan Tuncaboylu1, Fabian Friess2, Christian Wischke3

  • 1Institute of Biomaterial Science and Berlin-Brandenburg Centre for Regenerative Therapies, Helmholtz-Zentrum Geesthacht, Kantstr. 55, 14513 Teltow, Germany; Bezmialem Vakif University, Faculty of Pharmacy, 34093 Istanbul, Turkey.

Journal of Controlled Release : Official Journal of the Controlled Release Society
|June 19, 2018
PubMed
Summary
This summary is machine-generated.

This study introduces a novel shape-memory tube implant for controlled protein drug delivery. The implant enables on-demand release of therapeutic proteins, adapting to patient healing for enhanced regeneration.

Keywords:
Near infrared light triggered shape-recoveryOn-demand releasePoly(ɛ-caprolactone) networksProteinsShape-memory polymer

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Area of Science:

  • Biomaterials Engineering
  • Regenerative Medicine
  • Drug Delivery Systems

Background:

  • Precise control over protein drug release is crucial for optimizing patient-specific regeneration after surgery.
  • Current delivery systems often lack the adaptability needed to match dynamic healing processes.

Purpose of the Study:

  • To develop a multifunctional implant system for localized, on-demand release of various protein therapeutics.
  • To investigate the potential of shape-memory polymers for triggered drug expulsion.

Main Methods:

  • Fabrication of tubular multimaterial containers using poly(ɛ-caprolactone) networks with shape-memory properties.
  • Activation of shape-memory effect via external stimuli (heat or near-infrared light) to induce tube shrinkage.
  • Demonstration of payload expulsion using model proteins, including SDF-1α, in both open and sealed configurations.

Main Results:

  • Shape-memory tubes (SMT) successfully demonstrated diameter reduction upon thermal or NIR light stimulation.
  • Controlled release of proteins was achieved, enabling triggered add-on dosing or on-demand bolus/sustained release.
  • The system proved effective for various protein formulations (solution or gel).

Conclusions:

  • The developed shape-memory tube system offers a promising platform for on-demand protein delivery in regenerative medicine.
  • This technology has potential applications in tissue repair, including bone, nerve, and heart regeneration.
  • Further exploration is warranted, integrating with biomarker monitoring for personalized therapeutic strategies.