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Related Experiment Video

Updated: Feb 8, 2026

Lexical Decision Task for Studying Written Word Recognition in Adults with and without Dementia or Mild Cognitive Impairment
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Aging modulates fronto-temporal cortical interactions during lexical production. A dynamic causal modeling study.

E Hoyau1, A Roux-Sibilon1, N Boudiaf1

  • 1Univ. Grenoble Alpes, CNRS, LPNC UMR 5105, F-38000 Grenoble, France.

Brain and Language
|June 19, 2018
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Summary

Aging impacts brain connectivity during word retrieval. Older adults show altered fronto-temporal interactions, suggesting compensatory strategies for lexical production, unlike younger adults.

Keywords:
AgingDynamic causal modelingEffective connectivityFunctional MRILanguageLexical

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Area of Science:

  • Neuroscience
  • Cognitive Neuroscience
  • Neuroimaging

Background:

  • Lexical production relies on complex cerebral networks.
  • Aging can alter neural effective connectivity, potentially impacting cognitive functions like word retrieval.
  • Understanding age-related changes in brain networks is crucial for identifying compensatory mechanisms.

Purpose of the Study:

  • To investigate the effect of age on the effective connectivity of the cerebral network involved in lexical production.
  • To explore age-related differences in fronto-temporal interactions during an object naming task.
  • To test hypotheses regarding neural reserve and compensation mechanisms in aging.

Main Methods:

  • Functional magnetic resonance imaging (fMRI) was used to capture brain activity during an object naming task.
  • Dynamic Causal Modeling (DCM) was applied to analyze effective connectivity between four regions of interest: occipital cortex (OC), lateral temporal cortex (LTC), medial temporal cortex (MTC), and inferior frontal cortex (IFC).

Main Results:

  • Younger adults exhibited bi-directional interaction between the left inferior frontal cortex (IFC) and lateral temporal cortex (LTC), indicative of typical lexico-semantic processing.
  • Older adults demonstrated bi-directional interaction between the IFC and medial temporal cortex (MTC), but not between IFC and LTC.
  • This suggests older adults may employ a compensatory strategy involving supplemental access to conceptual and semantic retrieval processes, facilitated by top-down IFC-MTC connectivity.

Conclusions:

  • Aging alters effective connectivity within the lexical production network.
  • Older adults appear to utilize compensatory neural strategies, specifically engaging the medial temporal cortex (MTC) for semantic retrieval, unlike younger adults.
  • These findings highlight adaptive mechanisms in the aging brain for maintaining cognitive function.