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Correction: Cernencu et al. 3D Bioprinting of Biosynthetic Nanocellulose-Filled GelMA Inks Highly Reliable for Soft Tissue-Oriented Constructs. <i>Materials</i> 2021, <i>14</i>, 4891.

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Versatile graphene biosensors for enhancing human cell therapy.

George M Vlăsceanu1, Roxana-Maria Amărandi2, Mariana Ioniță1

  • 1Advanced Polymer Materials Group, University Politehnica of Bucharest, Gh Polizu 1-7, 011061 Bucharest, Romania; Faculty of Medical Engineering, University Politehnica of Bucharest, Gh Polizu 1-7, 011061 Bucharest, Romania.

Biosensors & Bioelectronics
|June 19, 2018
PubMed
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Graphene biosensors offer new ways to measure biomarkers for cancer treatment and tissue regeneration. Addressing design challenges will enable clinical use of these advanced cell therapy tools.

Keywords:
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Area of Science:

  • Biomedical Engineering
  • Cell Biology
  • Nanotechnology

Background:

  • Recent FDA and EMA approvals highlight advancements in cell-based therapies for cancer and other conditions.
  • Cell-based therapies require rigorous preclinical biomarker characterization for efficacy and safety.
  • Developing robust potency assays is critical for manufacturing advanced therapy medicinal products (ATMPs).

Purpose of the Study:

  • To review recent developments in graphene-enhanced biointerfaces for cell therapy applications.
  • To highlight the role of biosensors in measuring biomarkers for cancer treatment, diagnosis, and tissue regeneration.
  • To discuss challenges and solutions for clinical translation of graphene-based biosensors in cell therapy.

Main Methods:

  • Literature review focusing on graphene-enhanced biointerfaces and biosensor applications in cell therapy.
  • Analysis of technological advancements in biosensor design for quantitative biomarker measurement.
  • Discussion of preclinical characterization needs for cell and tissue-based products.

Main Results:

  • Graphene-based biosensors show promise for real-time monitoring of critical cell therapy functions.
  • Advancements in biosensor design are crucial for overcoming measurement challenges in cell therapy.
  • Examples of graphene-enhanced biointerfaces are presented for cancer treatment and tissue regeneration contexts.

Conclusions:

  • Graphene biosensors are emerging tools for advancing cell-based therapies.
  • Addressing current design limitations is key to realizing the potential of graphene biosensors for point-of-care testing.
  • Clinical-grade biosensors are essential for accelerating the development and application of human cell therapies.