Jove
Visualize
Contact Us

Related Concept Videos

Nursing Clinical Information System01:27

Nursing Clinical Information System

1.3K
Nursing Clinical Information System (NCIS)
A Nursing Clinical Information System (NCIS) is a specialized type of healthcare information system tailored to meet the unique needs of nursing practice. It incorporates the principles of nursing informatics to streamline information management and improve the quality of care delivery.
Critical attributes of NCIS include:
1.3K
Clinical Trials01:16

Clinical Trials

10.8K
Clinical trials are prospective experimental studies conducted on humans to determine the safety and efficacy of treatments, drugs, diet methods, and medical devices. Using statistics in clinical trials enables researchers to derive reasonable and accurate conclusions from the collected data, allowing them to make wise decisions in uncertain situations. In medical research, statistical methods are crucial for preventing errors and bias.
There are four phases in a clinical trial. A phase one...
10.8K
Clinical Trials: Overview01:11

Clinical Trials: Overview

5.0K
Clinical development focuses on how the drug will interact with the human body and encompasses four key phases of clinical trials, each serving a specific purpose in assessing the safety and effectiveness of new drugs. These phases overlap and build upon one another. Phase I involves a small group of healthy volunteers (typically 20-80 individuals) or, in cases where significant toxicity is expected, patients with the targeted disease, such as cancer or AIDS. The volunteers are tested for...
5.0K
Changes in Skin Color: Clinical Perspectives01:14

Changes in Skin Color: Clinical Perspectives

3.7K
The first thing a clinician sees is the skin, so the examination of the skin should be part of any thorough physical examination. Most skin disorders are relatively benign, but a few, including melanomas, can be fatal if untreated. A couple of the more noticeable disorders, albinism and vitiligo, affect the appearance of the skin and its accessory organs.
Albinism
Albinism is a genetic disorder that affects (completely or partially) the coloring of skin, hair, and eyes. The defect is primarily...
3.7K
COPD: Pathogenesis and Clinical Features01:20

COPD: Pathogenesis and Clinical Features

1.9K
Chronic obstructive pulmonary disease (COPD) is a group of lung conditions that progressively worsen over time, including chronic bronchitis and emphysema. This cluster of diseases collectively leads to a gradual and irreversible decline in lung function over time.
The primary cause for the onset of COPD is cigarette smoking and exposure to air pollution. These hazardous factors initiate a chain reaction within the lungs, resulting in chronic inflammation, damage to the airways, and a...
1.9K
Esophageal Perforation-II: Clinical Manifestations and Management01:28

Esophageal Perforation-II: Clinical Manifestations and Management

741
Esophageal perforations manifest in various clinical forms, influenced by factors such as the perforation's cause and location (cervical, intrathoracic, or intra-abdominal), the extent of contamination, and potential injury to adjacent mediastinal structures. The timing between the perforation occurrence and treatment initiation also affects the clinical presentation.
Clinical Manifestations:
741

You might also read

Related Articles

Articles linked to this work by shared authors, journal, and citation graph.

Sort by
Same author

The Ability to Relax Muscles in Chronic Pain Conditions in the General Population: A Cross-Sectional Study (The HUNT Pain Examination Study).

Physiotherapy research international : the journal for researchers and clinicians in physical therapy·2025
Same author

Enhancing integration of the dairy and beef sectors through application of assisted reproductive technologies: pregnancy outcomes following timed AI and timed ET in lactating dairy cows.

Animal reproduction·2025
Same author

Correction: Mentalization for Offending Adult Males (MOAM): study protocol for a randomized controlled trial to evaluate mentalization-based treatment for antisocial personality disorder in male offenders on community probation.

Trials·2025
Same author

Mentalisation-based treatment for antisocial personality disorder in males convicted of an offence on community probation in England and Wales (Mentalization for Offending Adult Males, MOAM): a multicentre, assessor-blinded, randomised controlled trial.

The lancet. Psychiatry·2025
Same author

Bridging the Gap: A Qualitative Study Exploring the Impact of the Involvement of Researchers With Lived Experience on a Multisite Randomised Control Trial in the National Probation Service in England and Wales.

Health expectations : an international journal of public participation in health care and health policy·2025
Same author

Predicting criminal offence in adolescents who exhibit antisocial behaviour: a machine learning study using data from a large randomised controlled trial of multisystemic therapy.

European child & adolescent psychiatry·2024
JoVE
x logofacebook logolinkedin logoyoutube logo
ABOUT JoVE
OverviewLeadershipBlogJoVE Help Center
AUTHORS
Publishing ProcessEditorial BoardScope & PoliciesPeer ReviewFAQSubmit
LIBRARIANS
TestimonialsSubscriptionsAccessResourcesLibrary Advisory BoardFAQ
RESEARCH
JoVE JournalMethods CollectionsJoVE Encyclopedia of ExperimentsArchive
EDUCATION
JoVE CoreJoVE BusinessJoVE Science EducationJoVE Lab ManualFaculty Resource CenterFaculty Site
Terms & Conditions of Use
Privacy Policy
Policies

Related Experiment Video

Updated: Feb 8, 2026

Human Egg Maturity Assessment and Its Clinical Application
08:51

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

20.2K

Buprenorphine-Clinically useful but often misunderstood.

Stephen Butler1

  • 1Pain Clinic, Uppsala University Hospital, Uppsala, Sweden.

Scandinavian Journal of Pain
|June 20, 2018
PubMed
Summary

Buprenorphine is a potent opioid analgesic with unique properties ideal for chronic pain management and opioid addiction treatment. It is not a respiratory depressant and can be used in renal failure, debunking common myths.

Keywords:
BuprenorphineIndicationsORL-1-receptor agonistOpioid receptorsdelta-Receptor-agonistkappa-Receptor antagonistmu-Receptor-agonist

More Related Videos

Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.9K
Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

2.0K

Related Experiment Videos

Last Updated: Feb 8, 2026

Human Egg Maturity Assessment and Its Clinical Application
08:51

Human Egg Maturity Assessment and Its Clinical Application

Published on: August 19, 2019

20.2K
Establishment of a Clinic-based Biorepository
07:50

Establishment of a Clinic-based Biorepository

Published on: May 29, 2017

6.9K
Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research
08:14

Author Spotlight: Developing Innovative Therapeutic Strategies for Hemorrhagic Shock Research

Published on: March 22, 2024

2.0K

Area of Science:

  • Pharmacology and Pain Management
  • Pharmacodynamics and Pharmacokinetics of Opioids

Background:

  • Common myths about buprenorphine, stemming from outdated animal data and early research, persist in pharmacology and pain management literature.
  • These myths include claims of a bell-shaped dose-response curve, a plateau effect, and an antagonist effect on other mu-opioid agonists, which are not observed in clinical practice.

Purpose of the Study:

  • To review current research on buprenorphine's pharmacodynamics and pharmacokinetics relevant to clinical practice.
  • To clarify misconceptions and highlight the drug's suitability for chronic pain and opioid addiction treatment.

Main Methods:

  • A narrative, topical review of relevant research publications.
  • Evaluation of new knowledge on buprenorphine's pharmacodynamics and pharmacokinetics.

Main Results:

  • Buprenorphine is a potent analgesic acting as an agonist on mu, delta, and ORL-1 receptors, and an antagonist at the kappa receptor.
  • It has active, analgesic metabolites (except norbup-3-glu); buprenorphine itself is not a respiratory depressant or sedative, though some metabolites are.
  • Buprenorphine is suitable for patients with renal failure, has a slow onset/long offset beneficial for chronic pain and addiction treatment, and enhances nerve blocks.

Conclusions:

  • Buprenorphine's unique pharmacodynamics and pharmacokinetics make it an effective opioid for most chronic pain conditions requiring opioid therapy.
  • It is a valuable alternative for chronic pain, including neuropathic and cancer pain, and for opioid abuse rehabilitation, offering an alternative to methadone.