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Updated: Feb 8, 2026

Digital PCR for Quantifying Circulating MicroRNAs in Acute Myocardial Infarction and Cardiovascular Disease
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Role of MicroRNAs in Renal Parenchymal Diseases-A New Dimension

Saeed Kamran Shaffi1, David Galas2, Alton Etheridge3

  • 1Department of Internal Medicine, Division of Nephrology, University of New Mexico, Albuquerque, NM 87131, USA. kshaffi@salud.unm.edu.

International Journal of Molecular Sciences
|June 20, 2018
PubMed

Insights

MicroRNAs (miRNAs) regulate gene expression and are vital for kidney development and function. Dysregulation of these small molecules is implicated in kidney diseases, offering potential therapeutic targets.

Area of Science:

  • Biochemistry
  • Molecular Biology
  • Nephrology

Background:

  • MicroRNAs (miRNAs) are key gene expression regulators discovered in 1993.
  • miRNAs are crucial for normal development and physiology.
  • miRNA dysregulation is linked to various diseases.

Purpose of the Study:

  • Review the role of miRNAs in renal development and physiology.
  • Examine miRNA involvement in kidney injury repair and disease pathogenesis.
  • Discuss miRNA detection methods and therapeutic potential.

Main Methods:

  • Literature review of scientific publications.
  • Analysis of miRNA function in renal contexts.
  • Overview of current detection techniques.

Main Results:

  • miRNAs are essential for normal kidney development and function.
  • Aberrant miRNA expression contributes to kidney disease.
  • miRNAs play a role in maladaptive repair after renal injury.

Conclusions:

  • miRNAs are critical regulators in kidney health and disease.
  • Understanding renal miRNAs can improve disease diagnosis and treatment.
  • miRNAs represent promising therapeutic targets for kidney disorders.
Keywords:
miRNAmiRNA detectionmiRNA in renal parenchymal DiseasesmiRNA-based therapeuticsmicro RNArenal parenchymal diseases

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