Related Experiment Video

Updated: Feb 8, 2026

Forward Genetic Approaches in Chlamydia trachomatis
09:03

Forward Genetic Approaches in Chlamydia trachomatis

Published on: October 23, 2013

13.3K

Association of Chlamydia trachomatis infections with preterm delivery; a systematic review and meta-analysis

Amjad Ahmadi1,2, Rashid Ramazanzadeh3,4, Koroush Sayehmiri5

  • 1Cellular and Molecular Research Center, Research Institute for Health Development, Kurdistan University of Medical Sciences, Pasdaran Street, Sanandaj, 66177-13446, Iran. microbiology90@gmail.com.

BMC Pregnancy and Childbirth
|June 20, 2018
PubMed

Insights

Chlamydia trachomatis (CT) infection is linked to a higher risk of preterm birth. This meta-analysis confirms a significant association between CT colonization and increased odds of premature delivery.

Area of Science:

  • Reproductive Health
  • Infectious Diseases
  • Perinatal Epidemiology

Background:

  • Premature birth is a leading cause of infant mortality globally.
  • Etiology of preterm birth varies significantly across different countries.
  • Chlamydia trachomatis (CT) is a prevalent sexually transmitted infection.

Purpose of the Study:

  • To conduct a meta-analysis investigating the association between Chlamydia trachomatis infections and preterm birth.
  • To quantify the risk of preterm delivery in women with CT infections.

Main Methods:

  • Systematic literature search across multiple databases (PubMed, Scopus, Google Scholar, etc.) for studies published between 1998-2014.
  • Analysis of 24 relevant articles using a random effects model.
  • Meta-regression used to examine relationships with data collection years, sample size, and CT prevalence; heterogeneity assessed using I² index.

Main Results:

  • The overall pooled prevalence of CT infections associated with preterm delivery was 0.13% (CI 95%: 0.11-0.16).
  • Prevalence varied by diagnostic method: PCR (0.06%), culture (0.17%), and serology (0.23%).
  • Women with CT infections had 2.28 times higher odds of preterm delivery (OR = 2.28, 95% CI: 1.64-3.16).

Conclusions:

  • A clear association exists between Chlamydia trachomatis colonization and preterm delivery.
  • CT infections significantly increase the risk of premature birth.
  • Findings are consistent across studies from multiple continents.
Abstract

Keywords:
Chlamydia trachomatisPreterm deliveryPreterm labor

More Related Videos

Live-Cell Forward Genetic Approach to Identify and Isolate Developmental Mutants in Chlamydia trachomatis10:32

Live-Cell Forward Genetic Approach to Identify and Isolate Developmental Mutants in Chlamydia trachomatis

Published on: June 10, 2020

4.6K
A Human Fallopian Tube Model for Investigation of C. trachomatis Infections09:11

A Human Fallopian Tube Model for Investigation of C. trachomatis Infections

Published on: August 11, 2012

13.4K

Related Concept Videos

Review and Preview01:10

Review and Preview

In statistics, several tools are used to interpret the data. Measures of central tendency represent the characteristics of the data, such as mean, median, and mode. Additionally, measures of variance like standard deviation and range are used to find the spread of data from the mean. Relative standing measures the distance between data locations. Commonly used measures of relative standings are percentile, z score, and quartiles.
Percentiles are a type of fractile that partition data into...
8.4K
Review and Preview01:13

Review and Preview

Data are individual items of information obtained from a population or sample. Data may be classified as qualitative (categorical), quantitative continuous, or quantitative discrete. Because it is not practical to measure the entire population in a study, researchers use samples to represent the population. A random sample is a representative group from the population chosen by using a method that gives each individual in the population an equal chance of being included in the sample. Random...
11.5K
Bacterial Phylum Chlamydiae01:29

Bacterial Phylum Chlamydiae

The phylum Chlamydiae or Chlamydiota is composed of a single order, Chlamydiales. This phylum consists entirely of obligate intracellular parasites that infect eukaryotic hosts. While human pathogens within this group have been studied extensively, the phylum encompasses many species capable of interacting with various eukaryotic organisms. Members of Chlamydiae are typically small cocci, approximately 0.5 μm in diameter, and exhibit a distinctive developmental cycle. As is characteristic...
581
Random and Systematic Errors01:20

Random and Systematic Errors

Scientists always try their best to record measurements with the utmost accuracy and precision. However, sometimes errors do occur. These errors can be random or systematic. Random errors are observed due to the inconsistency or fluctuation in the measurement process, or variations in the quantity itself that is being measured. Such errors fluctuate from being greater than or less than the true value in repeated measurements. Consider a scientist measuring the length of an earthworm using a...
15.2K
Directing Effect of Substituents: meta-Directing Groups01:09

Directing Effect of Substituents: meta-Directing Groups

Substituents on the benzene ring that direct an incoming electrophile to undergo substitution at the meta position are called meta directors. All meta directors either have a positive charge on the atom directly bonded to the ring or a partial positive charge. These groups function by withdrawing electrons from the ring through inductive and resonance effects. Consider the carbocation intermediates formed upon the addition of an electrophile on nitrobenzene at the...
6.0K
Systematic Sampling Method01:17

Systematic Sampling Method

Sampling is a technique to select a portion (or subset) of the larger population and study that portion (the sample) to gain information about the population. Data are the result of sampling from a population. The sampling method ensures that samples are drawn without bias and accurately represent the population. Because measuring the entire population in a study is not practical, researchers use samples to represent the population of interest.
Systematic sampling is one of the simplest methods...
13.4K