Related Experiment Video
Updated: Feb 8, 2026

Diagnosis and Surgical Treatment of Human Brucellar Spondylodiscitis
Published on: May 23, 2021
Case report: Diffuse hyperplastic perilobar nephroblastomatosis complicated by a unilateral Wilms tumour: diagnosis,
Bruce Gao1, Emeka Nzekwu2, Anthony Jonathan Cook3
1The University of Calgary, Cumming School of Medicine, 3330 Hospital Dr NW, Calgary, AB, T2N 4N1, Canada. bmgao@ucalgary.ca.
Background:
Nephroblastomatosis is an uncommon pathologic process characterized by the presence of persistent embryonic nephrogenic rests. Progression to Wilms tumour occurs in an estimated 35% of patients. Cure rates are based on histologic findings and disease stage and have improved from 10% in the 1920s to over 90% today.
Case Presentation:
We report a case of a 9-month-old female presenting with a 2-month history of abdominal distension. Ultrasonographic and computed tomographic assessments demonstrated features consistent with bilateral, diffuse, hyperplastic perilobar nephroblastomatosis (DHPLNB) for which she underwent chemotherapy. Magnetic resonance imaging 6 weeks following commencement of chemotherapy revealed a mass concerning for unilateral Wilms tumor for which she underwent partial nephrectomy. Pathology confirmed DHPLNB with a unilateral Wilms tumor.
Conclusion:
3.5 year radiographic follow up demonstrates complete recovery. To our knowledge, there are no similar cases with imaging depiction recently published. With potential for malignant transformation into Wilms tumour and low survival rate for late diagnosed Wilms tumors, it is important to recognize nephroblastomatosis early, both clinically and radiographically to improve overall patient prognosis.
Related Concept Videos
Diabetes: Symptoms, Diagnosis, and Complications
Diffusion
Diffusion
Hemodialysis II: Procedure and Complications
Pneumonia III: Complications and Assessment
Asthma-III: Symptoms and Complications
Classification of Asthma

