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Visualization of Pseudomonas aeruginosa within the Sputum of Cystic Fibrosis Patients
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Multi-resistant Pseudomonas aeruginosa ST235 in cystic fibrosis

Annabelle C Lee1, Andrew L Jones1

  • 1Department of Cystic Fibrosis, Royal Brompton & Harefield Foundation NHS Trust, United Kingdom.

Paediatric Respiratory Reviews
|June 20, 2018
PubMed

Insights

Chronic Pseudomonas aeruginosa infection impacts cystic fibrosis patients. Emerging multi-drug resistant strains like ST235 pose challenges, but novel cephalosporins show promise for treatment.

Area of Science:

  • Microbiology
  • Infectious Diseases
  • Pulmonology

Background:

  • Chronic Pseudomonas aeruginosa infection is a major factor in cystic fibrosis (CF) patient decline.
  • Specific hypervirulent and transmissible clonal strains of P. aeruginosa have been identified.
  • The ST235 strain of P. aeruginosa is an emerging multi-drug resistant (MDR) pathogen linked to severe infections.

Purpose of the Study:

  • To investigate the challenges posed by emerging MDR P. aeruginosa strains in CF.
  • To evaluate the potential efficacy of novel cephalosporins against MDR P. aeruginosa.

Main Methods:

  • Review of current literature on P. aeruginosa clonal strains in CF.
  • Analysis of P. aeruginosa ST235 characteristics, including multi-drug resistance.
  • Assessment of novel cephalosporin activity against MDR bacteria.

Main Results:

  • P. aeruginosa ST235 exhibits multi-drug resistance and increased virulence.
  • Novel cephalosporins demonstrate potential for treating infections caused by MDR bacteria.

Conclusions:

  • Effective treatment strategies are needed for chronic P. aeruginosa infections in CF.
  • Novel cephalosporins represent a promising therapeutic option against MDR P. aeruginosa strains like ST235.
Keywords:
Ceftolozane–tazobactamCystic fibrosisMolecular typingPseudomonas aeruginosa

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