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Updated: Feb 8, 2026

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis
04:30

A Murine Model of Stent Implantation in the Carotid Artery for the Study of Restenosis

Published on: May 14, 2013

26.3K

Statins reduce mortality and failure to rescue after carotid artery stenting

Muhammad Rizwan1, Muhammad Faateh1, Hanaa Dakour-Aridi1

  • 1Division of Vascular Surgery, Department of Surgery, Johns Hopkins University Hospital, Baltimore, Md.

Journal of Vascular Surgery
|June 20, 2018
PubMed

Insights

Statins significantly reduce mortality after carotid artery stenting (CAS), especially in patients experiencing complications like stroke or myocardial infarction (MI). These findings support encouraging statin use for all CAS patients.

Area of Science:

  • Cardiovascular Medicine
  • Interventional Cardiology
  • Pharmacology

Background:

  • Statins are proven to reduce risks after carotid endarterectomy.
  • The impact of statins on patients undergoing carotid artery stenting (CAS) is not well understood.

Purpose of the Study:

  • To investigate the effect of statin use on postoperative outcomes in patients who underwent CAS.

Main Methods:

  • Retrospective analysis of the Premier Healthcare Database (2009-2015).
  • Inclusion of 17,800 patients undergoing CAS.
  • Statistical analysis using univariate and multivariate models to assess statin's impact on outcomes.

Main Results:

  • 70% of patients were on statins; this group had more comorbidities.
  • Statin use was linked to a 64% reduction in mortality (P < .001) and an 18% reduction in stroke/death (P = .03).
  • Statin users showed significantly lower mortality (failure to rescue) if stroke or MI occurred (11.4% vs 30.8%; P < .001).

Conclusions:

  • Statin use is associated with reduced mortality and improved outcomes in patients experiencing major complications post-CAS.
  • Strong recommendation for statin use in all patients undergoing CAS.
Abstract

Keywords:
CASStatins

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