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Updated: Feb 8, 2026
08:38
Genome-wide Protein-protein Interaction Screening by Protein-fragment Complementation Assay PCA in Living Cells
Published on: March 3, 2015
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Case of posterior cortical atrophy (PCA) evolved to PCA-CBS
Nicola Salvadori1, Mirella Russo1, Leonardo Biscetti1
1Department of Medicine, Centre for Memory Disturbances, Laboratory of Neurochemistry, Section of Neurology, Perugia, Italy.
BMJ Case Reports
|June 20, 2018
Summary
This case study highlights posterior cortical atrophy (PCA) presenting with Gerstmann's and Balint's syndromes. Early symptoms included spatial disorientation and apraxia, progressing to dementia.
Area of Science:
- Neuroscience
- Neurology
- Geriatrics
Background:
- Posterior cortical atrophy (PCA) is a rare neurodegenerative syndrome.
- It often presents with visuospatial and apraxic deficits.
Observation:
- A 68-year-old lawyer exhibited progressive spatial disorientation and apraxia.
- Initial evaluation showed mild cognitive deficits and right frontoparietal hypometabolism on FDG-PET.
- Cerebrospinal fluid biomarkers ruled out Alzheimer's disease.
Findings:
- Neuropsychological testing revealed prominent visuospatial, praxis, and dysgraphia deficits.
- FDG-PET showed worsening right parietal hypometabolism, and MRI revealed right superior longitudinal fasciculus damage.
- The patient developed Gerstmann's and Balint's syndromes, with later onset of extrapyramidal signs, suggesting PCA with corticobasal syndrome features.
Implications:
- This case underscores the importance of recognizing PCA, especially when atypical presentations occur.
- Advanced neuroimaging and biomarker analysis are crucial for differential diagnosis.
- The progression to dementia highlights the severe impact of this neurodegenerative condition.
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