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Updated: Feb 8, 2026

Enrichment of Bacterial Lipoproteins and Preparation of N-terminal Lipopeptides for Structural Determination by Mass Spectrometry
Published on: May 21, 2018
The anti-staphylococcal lipolanthines are ribosomally synthesized lipopeptides
Vincent Wiebach1, Andi Mainz1, Mary-Ann J Siegert1
1Faculty II - Department of Chemistry, Technische Universität Berlin, Berlin, Germany.
Abstract:
The potent antibacterial lanthipeptide microvionin, isolated from a culture of Microbacterium arborescens, exhibits a new triamino-dicarboxylic acid moiety, termed avionin, and an unprecedented N-terminal guanidino fatty acid. We identified the corresponding biosynthetic gene cluster and reconstituted central steps of avionin biosynthesis in vitro. Genome mining and isolation of nocavionin from Nocardia terpenica revealed a widespread distribution of this lanthipeptide class, termed lipolanthines, which may be useful as future antimicrobial drugs.
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