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Related Concept Videos

[3,3] Sigmatropic Rearrangement of Allyl Vinyl Ethers: Claisen Rearrangement01:24

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The histone proteins have a flexible N-terminal tail extending out from the nucleosome. These histone tails are often subjected to post-translational modifications such as acetylation, methylation, phosphorylation, and ubiquitination. Particular combinations of these modifications form “histone codes” that influence the chromatin folding and tissue-specific gene expression.
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Two structural features of the DNA molecule provide a basis for the mechanisms of heredity: the four nucleotide bases and its double-stranded nature. The Watson-Crick model of double-helical DNA structure, proposed in 1952, drew heavily upon the X-ray crystallography work of researchers Rosalind Franklin and Maurice Wilkins. Watson, Crick, and Wilkins jointly received the Nobel Prize in Physiology or Medicine for their work in 1962. Franklin was, controversially, excluded from the prize for...
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A Vinyl Ether-Functional Polycarbonate as a Template for Multiple Postpolymerization Modifications.

Sangho Cho1,2,3, Gyu Seong Heo1,4, Sarosh Khan1

  • 1Department of Chemistry, Department of Chemical Engineering, Department of Materials Science & Engineering, and Laboratory for Synthetic-Biologic Interactions, Texas A&M University, P.O. Box 30012, 3255 TAMU, College Station, Texas 77842-3012, United States.

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|June 20, 2018
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Summary
This summary is machine-generated.

New vinyl ether-functionalized polycarbonates enable versatile post-polymerization modifications. These polymers form pH-responsive nanostructures with low cytotoxicity, suitable for biomedical applications.

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Area of Science:

  • Polymer Chemistry
  • Materials Science
  • Biomaterials

Background:

  • Developing functional polymers for post-modification is crucial for advanced applications.
  • Aliphatic polycarbonates offer tunable properties and biocompatibility.
  • Vinyl ether groups provide reactive handles for diverse chemical conjugations.

Purpose of the Study:

  • To synthesize and characterize vinyl ether-functionalized aliphatic polycarbonates (PMVEC).
  • To explore post-polymerization modification strategies using PMVEC.
  • To investigate the self-assembly and pH-responsive behavior of PMVEC-based block copolymers.

Main Methods:

  • Organobase-catalyzed ring-opening polymerization of a vinyl ether-functional cyclic carbonate monomer.
  • Post-polymerization modification via acetalization, thio-acetalization, and thiol-ene reactions.
  • Characterization of block copolymer self-assembly using dynamic light scattering and transmission electron microscopy.
  • Kinetics studies of acetal cleavage in acidic conditions and cytotoxicity assays.

Main Results:

  • Successful synthesis of PMVEC with pendant vinyl ether groups.
  • Demonstration of efficient conjugation with hydroxyl- and thiol-containing molecules.
  • Formation of self-assembled nanostructures from amphiphilic mPEG-b-PMVEC block copolymers.
  • Characterization of pH-dependent acetal cleavage kinetics and minimal cytotoxicity of the polymer system.

Conclusions:

  • Vinyl ether-functionalized polycarbonates serve as versatile platforms for polymer modification.
  • The developed block copolymers exhibit pH-responsive behavior and form stable nanostructures.
  • The polymer system demonstrates low cytotoxicity, indicating potential for biomedical applications.