Related Experiment Video

Updated: Feb 8, 2026

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels
05:31

Noninvasive Sampling of Mucosal Lining Fluid for the Quantification of In Vivo Upper Airway Immune-mediator Levels

Published on: August 7, 2017

11.0K

Abnormal Growth and Feeding Behavior in Upper Airway Obstruction in Rats

Ariel Tarasiuk1,2, Yael Segev3

  • 1Sleep-Wake Disorders Unit, Soroka University Medical Center, Beer-Sheva, Israel.

Frontiers in Endocrinology
|June 20, 2018
PubMed

Insights

Pediatric obstructive sleep apnea (OSA) can lead to growth issues and obesity, even after treatment. Studies show airway obstruction removal may not fully restore normal growth patterns in animal models.

Area of Science:

  • Pediatric Sleep Medicine
  • Endocrinology
  • Metabolic Syndrome

Background:

  • Pediatric obstructive sleep apnea (OSA) causes snoring and breathing issues, impacting sleep and potentially leading to growth problems, obesity, and metabolic syndrome.
  • Adenotonsillectomy, a common OSA treatment, often fails to fully resolve obesity risk, suggesting mechanisms beyond breathing restoration.
  • The link between upper airway obstruction (AO) and persistent changes in feeding, metabolism, and growth remains poorly understood.

Purpose of the Study:

  • To investigate persistent endocrine regulation abnormalities in feeding and growth following chronic upper airway obstruction removal in rats.
  • To explore metabolic regulation aspects unrelated to intermittent hypoxia in an animal model mimicking pediatric OSA.

Main Methods:

  • Utilized a rat model to simulate chronic upper airway obstruction (AO) and its removal.
  • Focused on analyzing endocrine regulation of feeding and growth, distinguishing effects from intermittent hypoxia.

Main Results:

  • Evidence indicates persistent abnormalities in endocrine regulation of feeding and growth after chronic AO removal.
  • Findings highlight metabolic regulation issues not solely attributable to intermittent hypoxia.
  • The animal model replicated key clinical features of pediatric OSA.

Conclusions:

  • Obstruction removal in OSA may not be sufficient to prevent a post-treatment tendency for abnormal growth.
  • Further research is needed to understand and address persistent metabolic and growth dysregulation in pediatric OSA.

Keywords:
growthmetabolismratssleepsleep-disordered breathingupper airway obstruction

More Related Videos

Assaying Predatory Feeding Behaviors in Pristionchus and Other Nematodes06:27

Assaying Predatory Feeding Behaviors in Pristionchus and Other Nematodes

Published on: September 4, 2016

10.4K
A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats13:24

A Procedure to Observe Context-induced Renewal of Pavlovian-conditioned Alcohol-seeking Behavior in Rats

Published on: September 19, 2014

13.3K

Related Concept Videos

Abnormal Proliferation02:23

Abnormal Proliferation

Under normal conditions, most adult cells remain in a non-proliferative state unless stimulated by internal or external factors to replace lost cells. Abnormal cell proliferation is a condition in which the cell's growth exceeds and is uncoordinated with normal cells. In such situations, cell division persists in the same excessive manner even after cessation of the stimuli, leading to persistent tumors. The tumor arises from the damaged cells that replicate to pass the damage to the...
5.2K
Arteries of the Upper Limbs01:12

Arteries of the Upper Limbs

The subclavian artery transitions into the axillary artery as it exits the chest and enters the axillary region. This artery is critical for supplying blood to the shoulder area, including the head of the humerus, through the humeral circumflex arteries. As the vessel continues into the upper arm or brachium, it becomes the brachial artery. This artery plays a key role in vascularizing the brachial region and bifurcates at the elbow into several branches. These branches include the deep...
2.5K
What is Behavior?00:54

What is Behavior?

Behaviors are actions that an organism engages in—they can be related to finding food, reproducing, defending against threats, and many other possible actions. Behaviors include activities related to the environment around the animal—such as migration—as well as social interactions within a species or population. Many behaviors involve motor output—that is, muscle movements—while others involve less visible actions, such as learning.
10.3K
Suctioning the Nasopharyngeal Airway01:29

Suctioning the Nasopharyngeal Airway

Nasopharyngeal suctioning is a procedure to remove secretions from the upper part of the respiratory tract that the patient cannot clear independently. It helps maintain airway patency and prevents complications such as aspiration pneumonia.
Equipment Required
3.6K
Suctioning the Oropharyngeal Airway01:25

Suctioning the Oropharyngeal Airway

In preparing for oropharyngeal airway suctioning, a nurse must gather all necessary equipment, including a suction unit with tubing, a prepackaged suction kit, sterile gloves, water or saline for irrigation, a water-soluble lubricant, and additional personal protective equipment (such as a gown, mask, and goggles) to control infections.
After assembling the equipment, the nurse should practice hand hygiene and don appropriate PPE according to infection control guidelines to avoid the...
963
Respiratory System Abnormal Finding I: Inspection and Percussion01:30

Respiratory System Abnormal Finding I: Inspection and Percussion

Respiratory system abnormalities are a significant concern in healthcare due to their potential to indicate underlying severe conditions like Chronic Obstructive Pulmonary Disease (COPD), asthma, and pneumonia. These abnormalities can often be detected through physical examination methods like inspection and percussion.
Inspection Findings
During an inspection, several findings may suggest the presence of respiratory distress or disease. Pursed-lip breathing, where exhalation is slowed by...
845