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Dysregulated MicroRNA Involvement in Multiple Sclerosis by Induction of T Helper 17 Cell Differentiation

Chen Chen1, Yifan Zhou1, Jingqi Wang1

  • 1Department of Neurology, The Third Affiliated Hospital of Sun Yat-sen University, Guangzhou, China.

Frontiers in Immunology
|June 20, 2018
PubMed

Insights

MicroRNAs (miRNAs) influence T helper 17 (Th17) cell differentiation in multiple sclerosis (MS). This review explores how miRNAs regulate Th17 cells in MS pathophysiology and identifies potential therapeutic targets.

Area of Science:

  • Neuroimmunology
  • Molecular Biology

Background:

  • Multiple sclerosis (MS) is an immune-mediated central nervous system disorder.
  • T helper 17 (Th17) cells are key players in MS-related neuroinflammation.
  • MicroRNAs (miRNAs) are implicated in MS disease activity and progression.

Purpose of the Study:

  • To review the mechanisms by which miRNAs regulate CD4+ T cell differentiation into Th17 cells in MS.
  • To explore the role of miRNAs in the pathophysiology of multiple sclerosis.
  • To identify potential miRNA targets for MS disease-modifying therapies.

Main Methods:

  • Literature review of studies on miRNAs, T helper cells, and multiple sclerosis.
  • Analysis of molecular mechanisms regulating T cell differentiation.
  • Identification of miRNA-gene interactions relevant to MS.

Main Results:

  • miRNAs play a crucial role in controlling the differentiation of CD4+ T cells towards the Th17 lineage.
  • Specific miRNAs are associated with disease activity, duration, and patterns in MS.
  • Dysregulation of miRNA pathways contributes to neuroinflammation in MS.

Conclusions:

  • miRNAs are significant regulators of Th17 cell differentiation in multiple sclerosis.
  • Targeting specific miRNAs offers a promising strategy for developing novel MS treatments.
  • Understanding miRNA-mediated pathways is essential for advancing MS therapeutics.
Keywords:
T helper 17 cellsexperimental autoimmune encephalomyelitismicroRNAmultiple sclerosistreatment

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