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Daptomycin associated eosinophilic pneumonia: case report and differential diagnoses
Sijan Basnet1, Niranjan Tachamo1, Rashmi Dhital1
1Department of Medicine, Reading Hospital and Medical Center, West Reading, PA, USA.
Daptomycin, an antibiotic for skin infections, can rarely cause eosinophilic pneumonia. This case highlights the importance of considering this rare side effect in patients with pneumonia-like symptoms during daptomycin treatment.
Area of Science:
- Pulmonology
- Infectious Diseases
- Pharmacology
Background:
- Daptomycin is a critical antibiotic for treating gram-positive bacterial infections, including skin and soft tissue infections and infective endocarditis.
- Adverse drug reactions can significantly impact patient outcomes and treatment adherence.
Observation:
- An 89-year-old male patient developed fever, dyspnea, and cough during daptomycin therapy for infective endocarditis.
- Imaging revealed bilateral interstitial infiltrates, and laboratory tests showed peripheral eosinophilia (6%).
Findings:
- The patient was diagnosed with eosinophilic pneumonia, a rare adverse effect attributed to daptomycin.
- Symptomatic improvement was observed after discontinuing daptomycin and commencing corticosteroid therapy.
Implications:
- Physicians should maintain a high index of suspicion for daptomycin-induced eosinophilic pneumonia in patients presenting with pneumonia-like symptoms.
- Early diagnosis and appropriate management, including drug cessation and corticosteroid use, are crucial for favorable outcomes.
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