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Updated: Feb 8, 2026

Methods to Classify Cytoplasmic Foci as Mammalian Stress Granules
Published on: May 12, 2017
Stress Granules and ALS: A Case of Causation or Correlation?
Nikita Fernandes1, Nichole Eshleman1, J Ross Buchan2
1Department of Molecular and Cellular Biology, University of Arizona, Tucson, AZ, USA.
Abstract:
Amyotrophic Lateral Sclerosis (ALS) is a fatal neurodegenerative disease characterized by cytoplasmic protein aggregates within motor neurons. These aggregates are linked to ALS pathogenesis. Recent evidence has suggested that stress granules may aid the formation of ALS protein aggregates. Here, we summarize current understanding of stress granules, focusing on assembly and clearance. We also assess the evidence linking alterations in stress granule formation and dynamics to ALS protein aggregates and disease pathology.
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